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Hello, I'm Chandan
Sen, a Professor at The Ohio
State University
Wexner Medical Center.
I direct the Comprehensive
Wound Center at Ohio State,
and also direct the
Center for Regenerative
Medicine and Cell-Based Therapies.
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Today I'm going to
address the overall topic
of genes in skin wound healing.
And in particular, I will be
addressing the significance
of non-coding genes,
and the microRNA
component of non-coding genes.
To a common person, when we talk
about wounds, the first thing that
comes to mind are nicks and cuts,
lacerations that can be caused
by some traumatic injury
or accident, abrasions.
But if these types of wounds
happen to a healthy human
we expect closure in a
reasonable time frame.
And if this is happening in an
adult this type of closure of wound
usually is a associated
with a scar response.
As long as the skin is kept
cleaned and the wound is kept
cleaned these types
of wounds are not
expected to be complicated
in a healthy human.
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There are various ways
of closing a wound.
It could be primary
intention, where the wound
is closed with suture material.
It could be secondary intention,
in which the wound is left open
and closes naturally without the
use of any suture material or such.
Finally, it could be tertiary
intention where the wound was left
open to heal by secondary
intention, and when it did not,
another mechanism of
closing it was adopted.
In this case it must be
made sure that the wound
is clean prior to it being closed.
