Genetic basis of neurological disease

Published on July 1, 2014   34 min

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Other Talks in the Series: The Genetic Basis of Neurological Disorders

So I'm Nicholas Wood. I'm Galton Professor of Genetics here at UCL. And I'm going to talk about the genetic basis of a neurological disease. My background is a mix of clinical work and academic work. And my group are involved in trying to understand, as the title suggests, the basis of a range of neurological diseases.
So to start this lecture, I just want to put up a very basic slide here, really describing the basis of almost any trait. Of course I want to concentrate on the neurological ones. But you can divide them in a number of ways. You can have classical Mendelian inheritance, non-Mendelian, and then a slight after thought, is the chromosomal rearrangements. The chromosome rearrangements often give rise to other boutique and specific syndromes. And I'm not going to be talking about those at all today. However what has become increasingly important for a range of neurological and neuropsychiatric conditions is the fact that we have various numbers of genes. So copy number variation is becoming more prominent. But most of this talk is concerned with the Mendelian and non-Mendelian factors. And I'm going to illustrate these predominantly with Parkinson's disease, which nicely is a model for these two concepts.