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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introducation
- The dual role of mitochondria in life and death
- Mitochondria: the Pandora's box
- The mitochondrial apoptogenic factors
- How does Pandora's box open?
- Two fundamental questions
- Bcl-2 family
- Three dimensional structure
- A hydrophobic pocket interacts with BH3 domains
- TM domain occupies Bax hydrophobic pocket
- Two functional classes of BH3-only proteins
- Bax under resting conditions
- Bax during apoptosis
- How antiapoptotic proteins protect cells
- Conclusion 1
- Two fundamental questions
- The PTP cytochrome c release model (1)
- The permeability transition pore
- The PTP cytochrome c release model (2)
- Opening the PTP raises questions
- What about VDAC?
- Bax channel model for cytochrome c release
- Bcl-2 and bacterial toxins are structuraly similar
- Bax pores
- Bax/VDAC channel model for cytochrom c release
- Lipidic pores/protein-lipid complex model
- Structure of phospholipids
- Bax lipidic pores
- Summary
- The role of mitochondrial fission in apoptosis
- Bax-induced mitochondrial fragmentation
- Fusion and fission machineries
- Mitochondrial fission in apoptosis
- A different view on mitochondria
- Loss of OPA1 function and mitochondrial fission
- Mitochondrial fission and cytochrome c release
- Perspectives
Topics Covered
- Cell death
- Apoptosis
- Mitochondria
- Mitochondrial membrane permeabilization
- Bcl-2
- Bax
- Permeability transition pore
- Cytochrome c
- Mechanistic explanations
- Cancer
- Degenerative diseases
Talk Citation
Martinou, J. (2007, October 1). Mitochondria in apoptosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/280/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jean-Claude Martinou has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.