The epidermis and blistering disorders: pemphigus

Published on May 4, 2014   57 min
0:00
The epidermis and blistering disorders. This lecture is on pemphigus.
0:07
Pemphigus vulgaris usually presents on oral and genital mucosa, and may also involve skin. The lesions are fragile bullae that lead to shallow erosions that heal very slowly. Biopsy shows acantholytic suprabasal cleft. Direct immunofluorescence of biopsy reveals epidermal deposits of IgG and complement in the intercerllular space. Indirect immunofluorescence of serum demonstrates so-called "intercellular" antibodies reacting with the cell membrane of stratified squamous epithelium.
0:44
Prior to the introduction of an effective therapy with oral coritcosteroids in the 1950s, the disease had a dismal natural course, with approximately 50% mortality rate at two years and about 100% mortality rate by five years after the onset of the disease. The mortality rate now is estimated at about 5%, and death is almost invariably due to complications of immunosuppressive therapy.
Hide

The epidermis and blistering disorders: pemphigus

Embed in course/own notes