Infection in the cystic fibrosis lung

Published on April 2, 2014   52 min

Other Talks in the Series: Respiratory Infection

My name is Stuart Elborn, I'm Professor of Respiratory Medicine at Queen's University, Belfast, and Director of the Center for Infection and Immunity. In this lecture, I'm going to describe some of the exciting new discoveries using second generation sequencing in identifying bacteria and other microorganisms in there airways of people with cystic fibrosis, and then go on to discuss some of the challenges that face us in cystic fibrosis care relating to the management of infection with antibiotics.
First of all, I'd like to orientate you around cystic fibrosis. This is the most common autosomal recessive disorder affecting Northwest Europeans that results in early death. It's a multi-system disorder because the genetic condition affects epithelial cells, and so all of our hollow organs are affected in this condition. The major part of the morbidity and mortality is in chronic sinopulmonary disease, with infection and inflammation in the airways resulting from bronchiectasis and progressive lung injury. This leads to respiratory failure. Other organ systems that are affected are the hepatobiliary system, the pancreatic ducts, the gastrointestinal tract, reproductive tracts in the vas deferens, and the endocrine pancreas is often also affected, probably as a result of pancreatic scarring rather than a primary defect, though there are some indications that there may also be some abnormalities of insulin metabolism.