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- Introduction
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1. Psychopharmacology: structural aspects of the brain
- Prof. Brian Leonard
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2. The nature of chemical neurotransmission
- Prof. Brian Leonard
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3. Psychotropic drugs
- Prof. Brian Leonard
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4. Psychopharmacology of anxiety disorders
- Prof. Brian Leonard
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5. Psychopharmacology of depression
- Prof. Brian Leonard
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6. Psychopharmacology of mania and schizophrenia
- Prof. Brian Leonard
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7. The role of stress and immune system in psychiatric disorders
- Prof. Brian Leonard
- Introduction to Genetic Investigations of Complex Traits
- Genetics and Pharmacokinetics of Psychotropic Drugs
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9. Genetics of phase I enzymes
- Prof. Aiming Yu
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10. Phase II metabolism
- Prof. Ann Daly
- Genetics and Pharmacodynamics of Psychotropic Drugs
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13. Pharmacogenetics of antidepressants
- Prof. Alessandro Serretti
- Clinical Applications of Psychopharmacogenetics
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14. Of genes and drugs: genetic determinants of adverse drug reactions
- Dr. Mario Masellis
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15. Cocaine and amphetamine addiction genetics
- Dr. Gerome Breen
- Archived Lectures *These may not cover the latest advances in the field
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18. Genetic determinants of metabolism: clinical applications in psychiatry
- Prof. Julia Stingl (formerly Kirchheiner)
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20. Genetic polymorphisms influencing response to lithium
- Prof. Alessandro Serretti
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21. Genetic determinants of antipsychotic-induced weight gain
- Prof. Gavin Reynolds
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24. Genetic determinants of agranulocytosis
- Dr. Michael Dettling
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25. Genetic polymorphisms influencing the response of antidepressants
- Prof. Alessandro Serretti
Printable Handouts
Navigable Slide Index
- Introduction
- Lithium
- Lithium has shown to reduce risk of suicide
- Lithium characterization
- Lithium disadvantages
- Lithium response
- Lithium response - brain imaging
- Lithium response -imaging ubnormalities
- Lithium response - mood disorders
- Factors influencing lithium response
- Clinical predictors of lithium prophylactic efficacy
- Definition of response
- Definition of response - not complete responders
- Response as a continuous variable
- Definition of response - number of episodes
- The role of genetics
- Evidences for genetic influence on lithium efficacy
- Genetic influence on lithium response - studies
- The mode of inheritance is hard to be established
- Heterogeneity may explain discrepancies
- Difficulties in identifying a pattern of transmission
- No certain susceptibility gene for lithium efficacy
- Lithium induces a number of effects at:
- Lithium: possible mechanism of action (1)
- Lithium - the things it does
- Lithium: possible mechanism of action (2)
- Lithium effect on cytoskeletal function
- Lithium inhibits the recycling of inositol substrates
- Serotonin involvement in lithium efficacy
- Lithium increased the levels of 5-HIAA
- Serotonin pathway
- Lithium increased the levels of transporter proteins
- The turnover of 5-HT is due to lithium treatment
- Dopamine pathway
- Lithium and GSK-beta3
- Lithium induced G-protein phosphorylation
- Lithium influences gene expression
- Mechanism of action of psychotrophic drugs
- Lithium and gene expression
- Lithium mechanism of action
- Pharmacogenetic studies (1)
- Pharmacogenetic studies (2)
- Definition of response in our studies
- Response index
- Inositol polyphasphate 1-phosphatase (INPP1)
- Gamma-1 isoenzyme of phospholipase C (PLCG1)
- PLCG1: conflicting results
- Tryptophan hydroxylase gene
- Methods
- Results (1)
- TPH variants/frequency of episodes vs. treatment
- Result (2)
- Result (3)
- Serotonin transporter gene
- 5-HTTLPR variants and EF vs. lithium treatment (1)
- 5-HTTLPR variants and EF vs. lithium treatment (2)
- Serotonin transporter gene and lithium prophylaxis
- Descriptive data of the sample (1)
- Descriptive data of the sample (2)
- Conclusions
- Lithium salts long-term response in bipolar illness
- GSK 3 beta is a key factor in signal transduction
- Results (4)
- Results (5)
- Mitochondrial DNA
- Pharmacogenetic studies
- Differences among pharmacogenetic studies
- Conclusions (1)
- Conclusions (2)
- Hopes (1)
- Hopes (2)
Topics Covered
- Lithium treatment in the long-term maintenance of mood disorders
- The issue of evaluating lithium response
- Role of genetic factors
- Mechanism of action of lithium candidate genes in lithium response
- Inositol polyphosphate 1- phosphatase (INNP1)
- Gamma-1 isoenzyme of phospholipase C (PLCG1)
- Tryptophan hydroxylase gene (TPH
- A218C)
- Serotonin transporter gene (5-HTTLPR)
- Glycogen synthase kinase 3-beta (GSK3B-50 T/C)
Links
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Talk Citation
Serretti, A. (2007, October 1). Genetic polymorphisms influencing response to lithium [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/IHJA9647.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Alessandro Serretti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.