Influence of neurotransmitter receptor variants on interactions with psychotropic drugs

Published on October 1, 2007 Updated on December 2, 2014   25 min

Other Talks in the Series: Psychopharmacogenetics

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This talk, we focus on influence of genetic variants in neurotransmitter receptors on the response with treatment with psychotropic drugs.
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The talk is divided into five parts, starting with a brief introduction. A second part is dedicated to genetic variants in dopamine receptors and transporters and the influence on treatment response. The third chapter summarizes the effect of genetic variants in the serotonergic system, followed by a chapter on genetic variants in other neurotransmitter systems and their influence on clinical outcome.
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Introduction-- The mainstay treatment
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of severe mental disorders, such as schizophrenia and bipolar disorders, is the use of psychotropic drugs. However, not all patients respond to treatment. 30 to 50% of treated patients fail to respond. And about 60 to 70% of treated patients develop long lasting and severe side effects, which can be life threatening.
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Influence of neurotransmitter receptor variants on interactions with psychotropic drugs

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