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1. Introduction
2. Earth is 70% ocean and 70% ocean bottom!
3. How can we access the deep ocean systems?
4. Deep ocean sediment sampling
5. Unknown actinomycete bacteria cultivated
6. New phylogenetic diversity: marine actinomycetes
7. Bioactive marine microbial metabolites
8. Problems with marine microbial drug discovery
9. Three species of Salinispora recognized
10. Chemical study - Salinispora tropica CNB-440
11. Salinosporamide A, a potent anticancer agent
12. Sal A proteasome enzymatic specificity
13. Sal A reactivity during binding to 20S proteasome
14. Ammosamides A and B - Mar 14 group
15. Ammosamides A and B
16. Ammosamides A and B cancer bioactivities
17. Cell cycle response to ammosamide B
18. Protein target of ammosamide B
19. Protein target of ammosamide B is myosin II
20. X-ray structure of myosin II
21. Predicted myosin II binding site (docking studies)
22. The MAR 4 actinomycetes - Streptomycetaceae
23. The MAR 4 actinomycetes metabolites
24. Napyradiomycins induce rapid cytotoxicity
25. Napyradiomycins and apoptosis in HCT-116 cells
26. Preparation of fluorescent coumarin derivatives
27. Two MAR 4 probes bind to the ER in HeLa cells
28. Immunoprecipitation leads to “Grp94” as target
29. Role of the Hsp90 proteins in cell regulation
30. Streptomyces strain CNH-287, a new species
31. X-ray structure of chlorizidine A
32. Reactivity of chlorizidine A
33. Synthesis of the chlorizidine A fluorescent probe
34. Incubation of chlorizidine A probe & HCT-116 cells
35. Immunoprecipitation leads to ID of ENO1
36. Crystal structure of human enolase 1
37. Concluding remarks
38. Acknowledgements

Topics Covered

• Structurally unprecedented marine bacterial metabolites
• Developing new molecules for the treatment of cancer
• Discovery of the protein targets of apoptosis-inducing metabolites
• Developing the potential of natural products to treat cancer by alternative mechanisms of action
• Discoveries of GRP94, myosin II and related cellular proteins as targets of new cytotoxins

Links

Series:

• Small Molecule Drug Discovery

Categories:

• Cancer
• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Oncology

Talk Citation

Fenical, W. (2021, September 23). Deep ocean microorganisms yield mechanistically-novel anticancer agents [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 5, 2023, from https://hstalks.com/bs/2645/.
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Publication History

• Published on September 23, 2013
• Reviewed on September 23, 2021

Financial Disclosures

• Prof. William Fenical has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.