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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- The global immune response of the lungs
- Dendritic cells (DCs)
- Localisation of DCs in epithelium
- DCs probe the mucosa for incoming antigen
- Activating DCs (1)
- Activating DCs (2)
- The dynamic behaviour of DCs in the airways
- Airway DCs capture inhaled FITC-labelled OVA
- What’s controlling dendritic cell traffic in the lung?
- Controlling responsiveness to the node T cell area
- Immunological synapse formation in the T cell area
- Peptide presentation by MHC class II molecules
- Cascade of costimulatory events
- DC determine the outcome of T cell priming
- CD11c^hi cells and induction of immunity in lungs
- Depletion of pDCs during priming
- Role of DCs in asthma?
- Airway inflammation in chronic asthma
- Th2 lymphocytes role in airway inflammation
- DC and the Th2 response
- DC role in allergic asthma
- How could we target DCs?
- Allergen exposure activation
- House dust mite fecal pellets
- Epithelial vs. DC expression of TLR4
- Epithelial TLR4 role in allergic sensitisation
- HDM driven inflammation and TLR4 antagonist
- Metabolic alterations
- Is uric acid released after HDM instillation?
- Uric acid and HDM sensitisation in mice
- Emerging model of Th2 sensitisation to HDM
- DC role in secondary immune response (1)
- DC role in secondary immune response (2)
- Role of airway DCs during ongoing inflammation
- DC depletion abolishes typical features of asthma
- What is the function of DCs in chronic asthma?
- Basement membrane thickening in asthma
- Shielding off is similar to body reaction to parasite
- Model of chronic airway remodelling in the lungs
- Collagen deposition & antigen uptake/recognition
- Antigen transport to MLN by DCs is enhanced
- Remodelled lung DCs promote Th2 response
- What happens if we present a neoantigen in vivo ?
- Sensitisation to neoantigen is induced
- Take home message
- Acknowledgments
Topics Covered
- The global immune response of the lungs
- Dendritic cells (DCs): localisation, trafficking, probing for antigen, activation, behaviour in airways during asthma and inflammation
- Controlling responsiveness to the node T cell area & Immunological synapse formation
- Peptide presentation by MHC class II molecules
- Cascade of costimulatory events
- Th2 lymphocytes role in airway inflammation
- Targeting DCs
- Allergen exposure activation
- Epithelial vs. DC expression of TLR4
- Metabolic alterations
- Uric acid and antigen sensitisation in mice
- DC depletion
- Basement membrane thickening in asthma
- Model of chronic airway remodelling in the lungs
- Collagen deposition & antigen uptake/recognition
- Presentation of neoantigen
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Lambrecht, B. (2013, September 22). Dendritic cells in asthma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/ANKU8122.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Bart Lambrecht has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Dendritic cells in asthma
Published on September 22, 2013
67 min
