Registration for a live webinar on 'Neuroleptic malignant syndrome' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Mycobacterium tuberculosis and the response of its host
-
2. The pathogenesis of tuberculosis
- Dr. William R. Bishai
-
3. Immune response and rational development of vaccines and biomarkers
- Prof. Dr. Stefan H. E. Kaufmann
-
4. Molecular mechanisms of drug resistance in M. tuberculosis
- Dr. Daniela Cirillo
- The epidemiology of tuberculosis
-
5. The basic epidemiology of tuberculosis (TB)
- Dr. David Dowdy
-
6. Global epidemiology of TB
- Dr. Philippe Glaziou
-
7. Social determinants of tuberculosis
- Dr. Knut Lönnroth
- The control of tuberculosis
-
8. Treatment of tuberculosis
- Dr. Jean-Pierre Zellweger
-
9. The End TB Strategy towards TB elimination 1
- Dr. Mario Raviglione
-
10. The End TB Strategy towards TB elimination 2
- Dr. Mario Raviglione
-
11. Financing TB care and control
- Dr. Christopher Fitzpatrick
- Dr. Andrea Pantoja
-
12. Tuberculosis and COVID-19
- Prof. Giovanni Battista Migliori
-
13. Multidrug resistant tuberculosis (MDR-TB): an update
- Dr. Simon Tiberi
-
14. Impact of HIV on tuberculosis in the developing world and how to manage it
- Prof. Anthony D. Harries
-
16. TB in children
- Prof. Ben J. Marais
-
17. Community engagement in tuberculosis care
- Ms. Lana Syed
-
18. India: the epicentre of global TB control
- Dr. Madhukar Pai
-
19. Community engagement in TB care
- Dr. Haileyesus Getahun
- Research and development for new approaches in the control of tuberculosis
-
20. Development of new regimens for tuberculosis
- Dr. Zhenkun Ma
-
22. Pharmacometrics in tuberculosis
- Prof. Charles A. Peloquin
-
23. Extrapulmonary tuberculosis
- Dr. Scott Heysell
-
24. The role of surgery in tuberculosis management
- Dr. Richard Zaleskis
- Archived Lectures *These may not cover the latest advances in the field
-
25. The development of current treatments for tuberculosis
- Dr. Andrew Nunn
-
26. The pathogenesis of tuberculosis
- Dr. William R. Bishai
-
27. Basics of tuberculosis epidemiology
- Prof. Frank Cobelens
-
29. The international approach to the control of tuberculosis
- Dr. Mario Raviglione
-
30. Public-private mix for TB care and control
- Dr. Mukund Uplekar
Printable Handouts
Navigable Slide Index
- Introduction
- Tuberculosis - the disease
- Pulmonary tuberculosis
- The tubercle bacillus
- Natural history of M.tb. - population level
- Natural history of M.tb. - individual level
- Initial exposure to M.tb.
- Early events of infection development
- Host response in infection development
- Granuloma formation (1)
- Granuloma formation (2)
- Infection outcome
- Latent TB infection, poorly understood
- LTBI
- Active TB
- The Dannenberg granuloma development model (1)
- The Dannenberg granuloma development model (2)
- New insights into active TB
- Transcriptional signatures associated with infection
- Type I IFN inhibits activation of macrophages
- TB and HIV
- Acknowledgements
Topics Covered
- TB disease
- The tubercle bacillus
- The natural history of TB
- M.tb. initial infection
- Granuloma formation
- Latent TB
- Active TB
- TB and HIV
- Animal models of TB pathogenesis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bishai, W.R. (2013, February 28). The pathogenesis of tuberculosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/ENOY4493.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Bishai hold patents related to recombinant BCG strains with potential use as TB vaccines.
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. My name is William Bishai.
I'm from the Kwazulu Natal Research Institute for TB and HIV in Johns Hopkins.
This presentation is on the pathogenesis of tuberculosis.
0:12
Tuberculosis is a human infection caused by Mycobacterium tuberculosis.
It can also be caused by two other closely related species that are members of the M.tb.
complex, M. bovis, and M. africanum.
While TB generally affects the lungs.
It can also lead to extrapulmonary TB in any part of the human body.
As in panel A, extensive pulmonary tuberculosis effects,
that's left lung, particularly in the left upper lobe
with many cavities and granulomatous inflammation,
but also cavities in the left lower lobe; B,
is cerebral tuberculosis with those grayish lesions of the brainstem and lower cerebrum;
C, splenic tuberculosis with multiple granulomas;
D, cardiac tuberculosis; E,
gastrointestinal TB with two large lesions; F,
renal tuberculosis; G TB of lymph nodes,
a very common occurrence; H, eye tuberculosis,
and in I and J,
extensive TB lesions of the skin.
1:22
In this talk, we'll focus on pulmonary tuberculosis and how the microbe, M.tb.
causes infection from a pathogenesis point of view.
Just to show the magnitude of the virulence of this pathogen,
the bottom-left panel shows a large cavity in a human lung.
On the right is a chest x-ray showing
a tennis ball-sized pulmonary cavity in
the right lower lobe of another individual affected by pulmonary tuberculosis.
Mycobacterium tuberculosis or the tubercle bacillus is a rod-shaped,