Share these talks and lectures with your colleagues
Invite colleaguesWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login
or review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Importance of innate immunity in the gut
- Mucosal tissues of the human body
- Intestinal pathogens and human disease
- Mucosal immune system: distinctive features
- Gut-associated lymphoid tissue (GALT)
- Structure of the GALT: small intestine
- Structure of the GALT: large intestine
- Mucus forms a key protective barrier in the gut
- Mucus secretion increases during infection
- Antimicrobial proteins protect the epithelium
- Epithelial cell transcytosis of secretory IgA
- Functions of secretory IgA
- Uptake and transport of antigen by M cells
- Microbial sensing regulates intestinal homeostasis
- Sensing of microbes occurs through PRR
- Innate immune signaling (1)
- Innate immune signaling (2)
- PRR signals in IEC
- MyD88 signals in IEC
- Control of inflammatory responses in the intestine
- Intestinal macrophages are anti-inflammatory
- Intestinal DC 'conditioning'
- Inflammatory bowel disease (IBD)
- Genome-wide association studies
- The enigma of NOD2 and Crohn's disease
- NOD2 signaling in response to bacterial MDP
- NOD2 signaling in IEC
- NOD2 signaling regulates myeloid cell function
- Autophagy also regulates IEC and myeloid cells
- Innate immune activation in IBD pathogenesis
- Innate intestinal inflammation, MyD88 dependent
- MyD88 activation drives intestinal inflammation
- Haematopoeitic MyD88 signals
- Immune dysregulation in chronic inflammation
- Innate lymphoid cells (ILC) drive innate IBD
- ILC provide early innate immune protection
- Additional distinct functional subsets of ILC
- Leukocyte populations and intestinal homeostasis
- Summary
- Acknowledgements
Topics Covered
- Mucosal tissues of the human body
- Intestinal pathogens
- Mucosal immune system: distinctive features
- Gut-associated lymphoid tissue (GALT)
- Structure of the GALT: small and large intestine
- Mucus, a key protective barrier
- Antimicrobial proteins protect the epithelium
- Epithelial cell transcytosis of secretory IgA
- Uptake and transport of antigen by M cells
- Microbial sensing regulates intestinal homeostasis
- Sensing of microbes occurs through PRR
- MyD88 signals in IEC
- Intestinal macrophages are anti-inflammatory
- Intestinal DC 'conditioning'
- Inflammatory bowel disease (IBD)
- Genome-wide association studies
- The enigma of NOD2 and Crohn's disease
- NOD2 signaling in response to bacterial MDP
- NOD2 signaling regulates myeloid cell function
- Autophagy also regulates IEC and myeloid cells
- MyD88 activation drives intestinal inflammation
- Haematopoeitic MyD88 signals
- Immune dysregulation in chronic inflammation
- Innate lymphoid cells (ILC) drive innate IBD
- Leukocyte populations and intestinal homeostasis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Maloy, K. (2013, January 31). Innate immunity in the intestine in health and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 28, 2021, from https://hstalks.com/bs/2486/.Publication History
Financial Disclosures
- Dr. Kevin Maloy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Innate immunity in the intestine in health and disease
Published on January 31, 2013
42 min