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1. Introduction
2. Importance of innate immunity in the gut
3. Mucosal tissues of the human body
4. Intestinal pathogens and human disease
5. Mucosal immune system: distinctive features
6. Gut-associated lymphoid tissue (GALT)
7. Structure of the GALT: small intestine
8. Structure of the GALT: large intestine
9. Mucus forms a key protective barrier in the gut
10. Mucus secretion increases during infection
11. Antimicrobial proteins protect the epithelium
12. Epithelial cell transcytosis of secretory IgA
13. Functions of secretory IgA
14. Uptake and transport of antigen by M cells
15. Microbial sensing regulates intestinal homeostasis
16. Sensing of microbes occurs through PRR
17. Innate immune signaling (1)
18. Innate immune signaling (2)
19. PRR signals in IEC
20. MyD88 signals in IEC
21. Control of inflammatory responses in the intestine
22. Intestinal macrophages are anti-inflammatory
23. Intestinal DC 'conditioning'
24. Inflammatory bowel disease (IBD)
25. Genome-wide association studies
26. The enigma of NOD2 and Crohn's disease
27. NOD2 signaling in response to bacterial MDP
28. NOD2 signaling in IEC
29. NOD2 signaling regulates myeloid cell function
30. Autophagy also regulates IEC and myeloid cells
31. Innate immune activation in IBD pathogenesis
32. Innate intestinal inflammation, MyD88 dependent
33. MyD88 activation drives intestinal inflammation
34. Haematopoeitic MyD88 signals
35. Immune dysregulation in chronic inflammation
36. Innate lymphoid cells (ILC) drive innate IBD
37. ILC provide early innate immune protection
38. Additional distinct functional subsets of ILC
39. Leukocyte populations and intestinal homeostasis
40. Summary
41. Acknowledgements

Topics Covered

• Mucosal tissues of the human body
• Intestinal pathogens
• Mucosal immune system: distinctive features
• Gut-associated lymphoid tissue (GALT)
• Structure of the GALT: small and large intestine
• Mucus, a key protective barrier
• Antimicrobial proteins protect the epithelium
• Epithelial cell transcytosis of secretory IgA
• Uptake and transport of antigen by M cells
• Microbial sensing regulates intestinal homeostasis
• Sensing of microbes occurs through PRR
• MyD88 signals in IEC
• Intestinal macrophages are anti-inflammatory
• Intestinal DC 'conditioning'
• Inflammatory bowel disease (IBD)
• Genome-wide association studies
• The enigma of NOD2 and Crohn's disease
• NOD2 signaling in response to bacterial MDP
• NOD2 signaling regulates myeloid cell function
• Autophagy also regulates IEC and myeloid cells
• MyD88 activation drives intestinal inflammation
• Haematopoeitic MyD88 signals
• Immune dysregulation in chronic inflammation
• Innate lymphoid cells (ILC) drive innate IBD
• Leukocyte populations and intestinal homeostasis

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Diseases, Disorders & Treatments
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on January 31, 2013

Financial Disclosures

• Dr. Kevin Maloy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.