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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Aspirin
- Aspirin-exacerbated respiratory disease (AERD)
- What we know about AERD
- AERD before and after sensitization
- Segmental lysine aspirin challenge
- Urinary LTE4 after aspirin
- Urinary LTE4
- Excess cysteinyl leukotrienes
- Genetic regulation of LTC4 synthase activity
- Cysteinyl leukotriene receptors
- Airways responsiveness to LTE4
- AERD involvement in LTE4 abnormalities
- Outline of eicosanoid metabolism (1)
- Bronchial mucosal LTC4 synthase expression
- AERD and prostanoids
- Outline of eicosanoid metabolism (2)
- PGE2 and leukotriene inhibition (1)
- Inhaled PGE2 abrogates bronchospasm
- Inhaled PGE2 increases in urinary LTE4
- Other effects of PGE2
- PGE2 and leukotriene inhibition (2)
- Airways COX-1 expression in asthma
- Airways COX-2 expression in asthma
- COX-2 inhibitors in aspirin sensitive asthma
- Urinary LTE4 excretion following challenge
- PGE2 and leukotriene inhibition (3)
- PGE2 production by fibroblast lines (2-3 weeks)
- PGE2 production by nasal epithelial lines (6 days)
- PGE2 and leukotriene inhibition (4)
- EP receptors expression
- Hypothesis
- CysLT1/2 and EP-1/2/3/4 receptors
- Global submucosal staining
- Immunoreactive inflammatory cells percentage
- The EP2 receptor alone is immunomodulatory
- Are there more LTE to be found?
- Data replication
- Biopsy stained with antibodies
- Double immunohistochemistry
- Results for EP1 and EP2
- Results for EP3 and EP4
- PGE2 and leukotriene inhibition (5)
- Summary: what we know
- Summary: what we still don't know
- Collaborators
- Thank you for your kind attention
Topics Covered
- Clinical features
- AERD as a disease of excessive leukotriene production
- Alterations in eicosanoid metabolism
- The protective role of Prostaglandin E2 (PGE2)
- Reduced PGE2 signalling as a mechanism for AERD
- The PGE2 receptor EP2 as a molecular target
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Corrigan, C. (2022, April 12). Aspirin exacerbated respiratory disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/JXAV9130.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Chris Corrigan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
