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• 52 min
  1. Principles of cytokine-receptor interactions and signal transduction

  • Dr. Xiaoxia Li
• 47 min
  2. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 74 min
  3. Cytokines and CD4 T Cells: dance partners at the immunology ball

  • Dr. William E. Paul
• 38 min
  4. The gamma c family of cytokines

  • Dr. Warren J. Leonard
• 29 min
  5. Interleukin-6: back to the future

  • Prof. Tadamitsu Kishimoto
• 59 min
  6. Regulation of the immune response to pathogens 1

  • Prof. Anne O’Garra
• 33 min
  7. Regulation of the immune response to pathogens 2

  • Prof. Anne O’Garra
• 23 min
  8. IL-17 cytokine family and receptors

  • Prof. Chen Dong
  • Dr. Seon Hee Chang
• 40 min
  9. The b common (bc) family of cytokines, receptors and ligands

  • Prof. Angel Lopez
  • Dr. Timothy Hercus
• 29 min
  10. TNF superfamily cytokines and receptors in the healthy and diseased immune system

  • Dr. Richard Siegel
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 49 min
  12. IL-1 as a key inflammatory regulator in autoinflammatory diseases

  • Dr. Raphaela Goldbach-Mansky
• 58 min
  13. Signaling for the interferon family of receptors and ligands and clinical implications

  • Prof. Leonidas Platanias
• 45 min
  14. Interferons as antivirals: translating basic research into clinical application

  • Prof. Eleanor N. Fish
• 49 min
  15. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 22 min
  16. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  17. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 49 min
  18. Receptor identification for alarmins and DAMPs

  • Dr. Joost J. Oppenheim
• 41 min
  19. Assays for cytokines and cytokine assay performance 1

  • Prof. Theresa Whiteside
• 39 min
  20. Assays for cytokines and cytokine assay performance 2

  • Prof. Theresa Whiteside
• 23 min
  21. Interleukin-7 and T cells

  • Dr. Scott Durum
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  22. Assays for cytokines and cytokine assay standardization

  • Prof. Theresa Whiteside

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Talk outline
3. The immune response in tuberculosis
4. Protective factors in the immune response to Mtb
5. Protection or pathogenesis: T cells in TB
6. Protection or pathogenesis: cytokines in TB
7. Protection or pathogenesis: resistant/susceptible
8. Mtb: resistant & susceptible mouse models
9. Factors that regulate host responses in TB
10. Potential regulatory roles for IL-10 in Mtb
11. Suggestive roles for IL-10 in human TB
12. IL-10 in mouse models of TB: conflicting reports
13. Enhanced IL-10 production in "susceptible" mice
14. Experimental overview
15. IL-10 is produced in the lung during Mtb infection
16. Mtb in the absence of IL-10 in BALB/c mice
17. Mtb H37Rv infection in the absence of IL-10
18. Enhanced protection to Mtb: IL-10 & Th1 response
19. IL-10 in immune regulation during Mtb infection
20. The human immune response in tuberculosis
21. Tuberculosis: a major human threat (epidemiology)
22. Difficulties in dealing with tuberculosis
23. Tuberculosis: a major human threat (Dx and Tx)
24. 2 billion people have "latent tuberculosis"
25. "Latent TB" into active TB: no test
26. Transcriptional signatures (latent vs. active TB)
27. Study design
28. Blood reflects cell migration throughout body
29. London the tuberculosis capital of Europe
30. Active vs. latent TB: distinct transcriptional profile
31. 393 transcripts derived from statistical filtering
32. Blood transcriptional signature validation (London)
33. TB is a global disease
34. Outliers in Latent and Active Tuberculosis
35. Transcriptional signature in active TB (London)
36. Active TB signature correlates with radiography
37. Active TB signature is diminished on treatment
38. TB signatures for treatment monitoring
39. Transcriptional modules
40. Finding common clusters across diseases
41. Classical versus modular approach
42. Modular signature of active TB: UK vs. SA (1)
43. TB signature distinct from other diseases
44. Modular signature of active TB: UK vs. SA (2)
45. IFN-inducible genes present in active TB patients
46. Bacterial pathogens can induce IFN production
47. Type 1 IFN can down-regulate IFN-gamma receptor
48. Mtb infection and type 1 IFN
49. Human disease and experimental models
50. Acknowledgements
51. Collaborators
52. The MRC National Institute for Medical Research
53. The Francis Crick institute

Topics Covered

• Tuberculosis (TB) as a major human threat
• T cells & cytokines in TB
• Difficulties in dealing with TB
• Resistant & susceptible TB mouse models
• Potential regulatory roles for IL-10 and factors that regulate host responses in TB
• "Latent TB" into active TB and distinct transcriptional signatures
• Finding common transcriptional clusters across diseases
• TB and type 1 IFN: Bacterial pathogen induction of IFN production and IFN-inducible genes present in active TB patients

Links

Series:

• Cytokines

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on December 27, 2012

Financial Disclosures

• Prof. Anne O’Garra has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.