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- Epidemiology and risk factors
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1. Epidemiology of COPD
- Dr. David Mannino
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2. COPD in never smokers
- Dr. Sundeep Salvi
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3. Genetics of chronic obstructive pulmonary disease (COPD)
- Prof. Martin Tobin
- Phenotypes of COPD
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4. COPD and asthma: similarities and differences
- Prof. Peter Barnes
- Pathophysiology and mechanisms of COPD
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5. The pathology of chronic obstructive pulmonary disease
- Prof. James Hogg
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6. The continuum of COPD: a physiological perspective
- Prof. Denis O'Donnell
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7. Inflammatory and immune mechanisms in COPD
- Prof. Peter Barnes
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8. Mechanisms of COPD exacerbations and relation to exacerbation therapy
- Prof. Wisia Wedzicha
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9. Protease-antiprotease balance
- Prof. Robert Stockley
- Therapy and management
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10. Updates in chronic obstructive pulmonary disease (COPD)
- Dr. Omar S. Usmani
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11. Long-acting bronchodilators in COPD
- Prof. Bart Celli
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12. Treatment of COPD exacerbations
- Prof. Antonio Anzueto
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13. Pulmonary rehabilitation: history, promise and problems
- Prof. Richard Casaburi
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14. Lung volume reduction: advances in COPD
- Dr. Nick Hopkinson
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15. New pharmacological therapies for COPD
- Prof. Peter Barnes
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16. The Salford lung study in COPD
- Dr. Dave Leather
- COPD case studies
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17. COPD treatment case I: COPD with “bronchitis attacks”
- Dr. Janwillem Kocks
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18. COPD treatment case II: COPD with asthma as child
- Dr. Janwillem Kocks
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19. COPD treatment case III: COPD with pre-diabetes
- Dr. Janwillem Kocks
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20. Tailoring care for advanced COPD
- Prof. Wissam Chatila
- Archived Lectures *These may not cover the latest advances in the field
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21. Alpha-1 antitrypsin deficiency: state of the art
- Dr. Jamie Stoller
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22. Oxidative stress in COPD
- Prof. William MacNee
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23. Managing co-morbidity in COPD
- Dr. John Hurst
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24. Clinical phenotypes of COPD
- Prof. Jørgen Vestbo
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25. Pulmonary rehabilitation: focusing on rehabilitative exercise
- Prof. Richard Casaburi
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26. Genetics of COPD
- Prof. Ian Hall
Printable Handouts
Navigable Slide Index
- Introduction
- Oxidants and antioxidant balance in the lungs
- Oxidants and antioxidants in the lungs
- Oxidative stress in COPD overview (1)
- Measurements of oxidative stress
- Synthesis of nitric oxide (NO)
- Nitrosative stress in COPD
- Mechanisms of membrane lipid peroxidation
- 4-hydroxy-2-nonenal-adducts in COPD
- Does oxidative stress occur in COPD?
- Smoke induced emphysema in Nrf2 KO mice
- Decline in NRF2-regulated antioxidants in COPD
- Nrf2 and oxidative stress relationship in COPD
- Regulation of NRF2 in COPD patients
- NRF2 targeting with CDDO
- What are the consequences of OS in COPD?
- Model of histone acetylation and deacetylation
- Effect of smoking and COPD on HDAC2
- Nitration and HDAC2 activity
- Smoke induced oxidative stress effects
- Emphysema: apoptosis
- Apoptosis and VEGF in emphysematous lungs
- Apoptosis and oxidative stress
- Decreased proteins in lungs of COPD patients
- Molecular alterations in COPD lungs
- Molecular alterations in COPD muscles
- Protease / antiprotease
- NRF2 way of protection against emphysema
- NAC attenuates elastase-induced emphysema
- Accelerated aging
- Free radical theory of aging or senescence
- Accelerated aging in COPD
- SIRT-1 is decreased in the lungs in COPD
- SMP-30 and age-associated deterioration
- Effects of decreased SIRT1
- Pathogenic triad of COPD
- Mucus hypersecretion
- Oxidants and mucin production
- Airway remodelling
- A link between oxidative injury and fibrosclerosis
- Immune modulation
- The nature of small-airway obstruction in COPD
- HO1 prevents smoke induced B-cell infiltrates
- Oxidative stress role in auto-immune response
- Oxidative stress in COPD: summary
Topics Covered
- The involvement of oxidative stress in the pathogenic mechanisms of COPD
- Downregulation of antioxidant defenses
- Enhanced inflammation
- Apoptosis
- Protease/antiprotease imbalance
- Accelerated aging
- Immunemodulation
- Potential for targeted therapy
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
MacNee, W. (2012, July 31). Oxidative stress in COPD [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/2364/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. William MacNee has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.