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1. Mononuclear phagocytes - origins, fates and functions
- Prof. Steffen Jung
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2. Transcription factors in macrophage differentiation
- Dr. Michael Sieweke
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3. Fetal macrophages
- Prof. Paul Martin
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4. The alveolar macrophage
- Dr. Ronald G. Crystal
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5. Airway macrophages in health and disease
- Prof. Tracy Hussell
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6. Intestinal macrophages - heterogeneity, origins and functions
- Prof. Allan Mowat
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7. Osteoclasts: what do they do and how do they do it?
- Prof. Steven L. Teitelbaum
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8. The biology of Fc receptors and complement receptors
- Prof. Steven Greenberg
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10. Tumour-associated macrophages
- Prof. Michele De Palma
- Dr. Mario Squadrito
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11. The recognition of pathogens by C-type lectins
- Prof. Gordon D. Brown
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12. Macrophage phagocytosis
- Prof. Joel Swanson
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13. Macrophage CD36 and atherosclerosis
- Dr. Maria Febbraio
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14. Toll-Like receptor signaling and the innate immune response
- Dr. Kate Fitzgerald
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15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria
- Prof. Ricardo Gazzinelli
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17. Triggering receptors expressed on myeloid cells (TREM)
- Dr. Daniel W. McVicar
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18. Influence of eicosanoid lipid mediators on macrophage innate immune functions
- Prof. Marc Peters-Golden
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19. Macrophage paired receptor interactions
- Prof. Neil Barclay
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20. Macrophage heterogeneity in atherosclerosis regression
- Prof. Edward Fisher
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21. Gaucher disease: from lysosomal storage to immunopathology
- Prof. Johannes M.F.G. Aerts
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22. Macrophage in asthma
- Prof. Douglas Robinson
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23. The macrophage mannose receptor
- Dr. Luisa Martinez-Pomares
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24. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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25. EGF-TM7 receptors
- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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26. Macrophages in helminth infection
- Prof. Judith Allen
- Archived Lectures *These may not cover the latest advances in the field
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27. Immunosuppressive mechanisms in myeloid cells
- Prof. Dmitry Gabrilovich
Printable Handouts
Navigable Slide Index
- Introduction
- Transcription factors in macrophage differentiation
- Differentiated cells
- Definition by function
- Definition by phenotype
- Definition by ontogeny
- Hematopoietic lineage
- Macrophage lineage
- Macrophage transcription factors
- M-CSF cytokine sensitivity
- Transcription factor control
- Gain of function vs. loss of function mutations
- C/EBPalpha KO
- PU.1 KO (1)
- PU.1 KO (2)
- Early lineage commitment
- Commitment
- Transcription factor-cytokine interaction
- Ectopic expression (1)
- Ectopic expression (2)
- Ectopic expression (3)
- Summary I
- Levels
- Cross inhibition
- Balance (1)
- Balance (2)
- Balance (3)
- Successive competition
- Combinatorial control
- Integrated inhibition and cooperation
- Changing complexes
- Summary II
- Enhancer definition
- Cell type specific enhancers
- ChIP-Seq enhancer definition
- Comparing enhancers from different cell types
- Cell type specific enhancer signature (1)
- Cell type specific enhancer signature (2)
- Global combinatorial enhancers
- Polarization
- Summary III
- Control of cellular proliferation during differentiation
- Recalling hematopoietic differentiation
- Maf transcription factors
- Maf transcription factors and cell differentiation
- Maf overexpression
- MafB overexpression
- Maf/Myb in macrophage differentiation
- Summary IV
- Differentiation and cell cycle arrest are linked
- MafB-/- macrophage differentiation
- MafB,c-Maf parallel expression
- MafB/c-Maf DKO macrophage differentiation
- Differentiation and cell cycle arrest are linked
- Differentiation & cell cycle arrest dissociation (1)
- Differentiation & cell cycle arrest dissociation (2)
- Mature adult macrophages
- Unlimited self renewal
- What is self renewal?
- Maintained macrophage identity
- Functional tissue integration
- Non tumorigenic cells
- c-Myc and KLF-4 dependence
- Summary V
- Thank you
- References (1)
- References (2)
- References (3)
- References (4)
- References (5)
Topics Covered
- Control of cellular identity and cell numbers
- Gain and loss of function approaches
- Transcription factor/cytokine interplay
- Mechanism: transcription factor levels, balance and combinatorial control
- Enhancer definition of macrophage identity
- Differentiation and cell cycle control
Links
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Talk Citation
Sieweke, M. (2012, June 14). Transcription factors in macrophage differentiation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 4, 2024, from https://doi.org/10.69645/USGV8552.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Michael Sieweke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.