- View the Talks
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66 min
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52 min
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49 min
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32 min
- Archived Lectures *These may not cover the latest advances in the field
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53 min
Topics Covered
- TB-immune reconstitution inflammatory syndrome (IRIS) is a common complication of combined antitubercular and antiretroviral therapy
- The two forms of IRIS: paradoxical and unmasking
- Lack of a diagnostic test for TB-IRIS
- Expansion of Interferon gamma secreting T cells is associated with TB-IRIS
- Multiple cytokines are elevated in TB-IRIS, many of myeloid origin
- Benefits of adjunctive corticosteroid therapy in TB-IRIS
- Steroid therapy reduces the levels of IL-6, IL-10, IL-12p40, TNF, Interferon-gamma and CXCL-10 in TB-IRIS patients
- Suppurative necrosis may occur in TB-IRIS, implying a role for neutrophils
- Evidence of a prominent role for myeloid cells in the pathogenesis of TB-IRIS
Links
Series:
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Therapeutic Areas:
Talk Citation
Wilkinson, R. and Meintjes, G. (2012, April 3). The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 14, 2022, from
https://hstalks.com/bs/2279/.
Publication History
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Published on April 3, 2012
Financial Disclosures
- Prof. Robert Wilkinson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Graeme Meintjes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.