An introduction to the world of microbes
40 min
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42 min
1. Historic introduction to innate immunity- Prof. Heiko Herwald
- Prof. Arne Egesten
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52 min
2. Evolution of innate immunity- Prof. Jim Kaufman
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25 min
3. The phagocytic synapse in distinguishing particulate and soluble stimuli- Prof. David Underhill
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23 min
4. How bacterial pathogens avoid phagocyte killing- Dr. Thomas Areschoug
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43 min
5. Origin of myeloid cells- Prof. Frederick A. Geissmann
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67 min
6. Dendritic cells- Prof. Muriel Moser
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38 min
7. Eosinophil biology and disorders associated with eosinophilia- Dr. Thomas B. Nutman
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60 min
8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity- Prof. Steven A. Porcelli
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50 min
9. Innate-like B cells- Prof. John F. Kearney
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58 min
10. Cytoplasmic innate immune sensors- Prof. Seth Masters
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76 min
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28 min
12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome- Prof. Robert Wilkinson
- Prof. Graeme Meintjes
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37 min
13. Antimicrobial peptides in the innate immune system of the lung- Prof. Dr. Pieter S. Hiemstra
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49 min
14. Chemokines and their receptors: their biology and therapeutic relevance- Dr. Amanda Proudfoot
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45 min
15. Heat shock proteins and their role in the immune regulation of inflammation- Prof. Willem Van Eden
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42 min
16. Tissue damage control confers host tolerance to infection- Dr. Miguel P. Soares
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22 min
17. Autophagy as a barrier to infection- Prof. Michele Swanson
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42 min
18. Innate immunity in the intestine in health and disease- Prof. Kevin Maloy
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51 min
19. Dendritic cells and the eye: their role in the ocular immune response- Prof. John V. Forrester
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26 min
20. Mononuclear phagocytes and HIV infection- Dr. Guido Poli
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41 min
21. Th17 cells and innate immunity- Prof. Mihai Netea
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37 min
22. Epigenetic regulation of innate immunity- Dr. Osamu Takeuchi
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66 min
23. Intracellular DNA sensing pathways- Prof. Veit Hornung
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52 min
24. Physiology of innate immunity- Prof. Keith W. Kelley
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49 min
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32 min
26. Regulation of type 2 immunity by basophils- Prof. David Voehringer
- Archived Lectures *These may not cover the latest advances in the field
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53 min
27. TLRs, NLRs, DAMPs and PAMPs- Prof. Luke O'Neill
Printable Handouts
Navigable Slide Index
- Introduction
- Disease in Cape town
- A triple coincidence that leads to HIV-TB-IRIS
- Antiretroviral therapy improves immunity
- Pathological immunity may be restored by ART
- A wide range of IRIS conditions
- Two forms of IRIS associated with tuberculosis
- Paradoxical TB-IRIS
- Clinical manifestations of paradoxical TB-IRIS
- Histopathology of IRIS
- How significant is IRIS?
- Diagnosing IRIS
- Challenges in diagnosing IRIS
- Pathogenesis of TB-IRIS
- IFN-gamma secreting T cells and TB-IRIS (1)
- HIV-TB-IRIS and M. tuberculosis specific T cells
- T cell expansion & contraction in IRIS & non-IRIS
- T cell expansion further investigation
- IFN-gamma secreting T cells and TB-IRIS (2)
- What is the role of cytokines?
- Cytokine and MMP analysis
- Myeloid origin pro-inflammatory cytokines
- Supernatant cytokines of myeloid origin
- Myeloid origin serum pro-inflammatory cytokines
- Multiply elevated cytokines accompany TB-IRIS
- Management of TB-IRIS
- Randomized trial of prednisone vs. placebo
- Primary endpoint
- Secondary endpoints
- C-reactive protein
- Immunological analysis
- Th1 contraction & expansion: corticosteroids
- Interleukin-6
- Interleukin-10
- Interleukin-12p40
- Tumor necrosis factor
- Interferon-gamma
- Interferon gamma inducible protein 10 (CXCL10)
- Further evidence of innate immune involvement
- Suppurative necrosis may accompany TB-IRIS
- A potential role for neutrophils
- Uncharacteristic cavitation in HIV-TB
- MMP genes and endogenous inhibitors
- In vitro secretion of matrix metalloproteinases
- Serum level of matrix metalloproteinases
- Conclusions: MMP in TB-IRIS
- Conclusions: TB-IRIS
- Acknowledgements
Topics Covered
- TB-immune reconstitution inflammatory syndrome (IRIS) is a common complication of combined antitubercular and antiretroviral therapy
- The two forms of IRIS: paradoxical and unmasking
- Lack of a diagnostic test for TB-IRIS
- Expansion of Interferon gamma secreting T cells is associated with TB-IRIS
- Multiple cytokines are elevated in TB-IRIS, many of myeloid origin
- Benefits of adjunctive corticosteroid therapy in TB-IRIS
- Steroid therapy reduces the levels of IL-6, IL-10, IL-12p40, TNF, Interferon-gamma and CXCL-10 in TB-IRIS patients
- Suppurative necrosis may occur in TB-IRIS, implying a role for neutrophils
- Evidence of a prominent role for myeloid cells in the pathogenesis of TB-IRIS
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Talk Citation
Wilkinson, R. and Meintjes, G. (2012, April 3). The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 24, 2021, from https://hstalks.com/bs/2279/.Publication History
Financial Disclosures
- Prof. Robert Wilkinson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Graeme Meintjes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome
Published on April 3, 2012
28 min
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