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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Disease in Cape town
3. A triple coincidence that leads to HIV-TB-IRIS
4. Antiretroviral therapy improves immunity
5. Pathological immunity may be restored by ART
6. A wide range of IRIS conditions
7. Two forms of IRIS associated with tuberculosis
8. Paradoxical TB-IRIS
9. Clinical manifestations of paradoxical TB-IRIS
10. Histopathology of IRIS
11. How significant is IRIS?
12. Diagnosing IRIS
13. Challenges in diagnosing IRIS
14. Pathogenesis of TB-IRIS
15. IFN-gamma secreting T cells and TB-IRIS (1)
16. HIV-TB-IRIS and M. tuberculosis specific T cells
17. T cell expansion & contraction in IRIS & non-IRIS
18. T cell expansion further investigation
19. IFN-gamma secreting T cells and TB-IRIS (2)
20. What is the role of cytokines?
21. Cytokine and MMP analysis
22. Myeloid origin pro-inflammatory cytokines
23. Supernatant cytokines of myeloid origin
24. Myeloid origin serum pro-inflammatory cytokines
25. Multiply elevated cytokines accompany TB-IRIS
26. Management of TB-IRIS
27. Randomized trial of prednisone vs. placebo
28. Primary endpoint
29. Secondary endpoints
30. C-reactive protein
31. Immunological analysis
32. Th1 contraction & expansion: corticosteroids
33. Interleukin-6
34. Interleukin-10
35. Interleukin-12p40
36. Tumor necrosis factor
37. Interferon-gamma
38. Interferon gamma inducible protein 10 (CXCL10)
39. Further evidence of innate immune involvement
40. Suppurative necrosis may accompany TB-IRIS
41. A potential role for neutrophils
42. Uncharacteristic cavitation in HIV-TB
43. MMP genes and endogenous inhibitors
44. In vitro secretion of matrix metalloproteinases
45. Serum level of matrix metalloproteinases
46. Conclusions: MMP in TB-IRIS
47. Conclusions: TB-IRIS
48. Acknowledgements

Topics Covered

• TB-immune reconstitution inflammatory syndrome (IRIS) is a common complication of combined antitubercular and antiretroviral therapy
• The two forms of IRIS: paradoxical and unmasking
• Lack of a diagnostic test for TB-IRIS
• Expansion of Interferon gamma secreting T cells is associated with TB-IRIS
• Multiple cytokines are elevated in TB-IRIS, many of myeloid origin
• Benefits of adjunctive corticosteroid therapy in TB-IRIS
• Steroid therapy reduces the levels of IL-6, IL-10, IL-12p40, TNF, Interferon-gamma and CXCL-10 in TB-IRIS patients
• Suppurative necrosis may occur in TB-IRIS, implying a role for neutrophils
• Evidence of a prominent role for myeloid cells in the pathogenesis of TB-IRIS

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. Robert Wilkinson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Graeme Meintjes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.