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1. Introduction
2. Role of virus infection in asthma
3. Disease exacerbations
4. The common cold viruses
5. Detection methods
6. Virus infections and asthma exacerbations
7. Asthma exacerbations - etiology
8. Asthmatics and LRT illness
9. Deficient IFN-beta production in asthma
10. IFN-lambda also deficient in asthmatics
11. Type III (lambda) IFNs deficient in BAL cells
12. Th1 responses related to asthma severity
13. IL-12 deficient in asthma
14. IL-18 also deficient in asthma
15. IL-15 links innate and adaptive immunity
16. IL-15 deficient in asthmatics in vivo
17. IL-15 induction by RV deficient in BAL cells
18. IL-15 deficiency related to virus load in vivo
19. IFN-alpha induction in DCs deficient in asthma
20. Increased chest symptoms and falls in PEF
21. Airway inflammation in asthmatics
22. Symptoms in AHR related to virus load
23. Specific antiviral approaches
24. Oseltamivir
25. Non-specific antiviral approaches
26. Safety study of IFN-beta in asthma
27. The macrolide azithromycin induces IFNs
28. TELICAST study
29. Conclusions: viruses in asthma exacerbations

Topics Covered

• Role of viruses in asthma exacerbations
• Huge clinical problem unmet by current therapies
• Viruses major cause in all age groups
• Deficient anti-viral immunity in asthma
• Potential therapies; specific anti-virals and broad-spectrum approaches

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011

Financial Disclosures

• Prof. Sebastian Johnston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.