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1. Intro slide
2. Outline
3. Causes of late onset dementia
4. Causes of early onset dementia
5. The size of the problem
6. Risk factors for AD
7. Familial AD (1)
8. Familial AD (2)
9. How common are AD gene mutations?
10. What are the earliest pathological changes in AD?
11. Site of hippocampus in the medial temporal lobe
12. Evolution of tangles in AD
13. Staging of neurofibrillary tangles in AD
14. Cognitive features of AD (1)
15. CANTAB PAC task
16. PAL: errors at 6-pattern stage at presentation
17. Autobiographical memory in AD and FTD
18. Cognitive features of AD (2)
19. Cognitive features of AD (3)
20. Cognitive features of AD (4)
21. Neuropsychiatric features of AD
22. AD: Diagnostic Criteria
23. Pre-dementia AD
24. Criteria for MCI
25. Diagnostic methods
26. Cambridge MCI study
27. PAL: errors at 6-pattern stage at presentation
28. Conversion to AD on follow up
29. PAL: outcome at 36 months at presentation
30. Predictors of conversion
31. Imaging
32. Structural brain imaging: MRI
33. 3D T1-W MRI: measurement of regions of interest
34. Hippocampal volumes overlap
35. Serial coregistration of MRI
36. Patient with early AD: MRI - hippocampus
37. 12 months later: MRI - hippocampus shrinkage
38. Atrophy rates: 12 patients with AD and 14 controls
39. FDG-PET + MRI coregistration
40. Method
41. FDG-PET finding in MCI and AD
42. The posterior cingulate: BA 31/23/29/30
43. Metabolic PET studies: summary
44. Atypical presentations
45. Potential aims of treatment
46. Delay of symptomatic decline
47. Drug treatments for dementia
48. General principal underlying the use of AChEi
49. The bottom line
50. Cholinesterase inhibitors
51. Management

Topics Covered

• Basic epidemiological facts on AD
• Typical and atypical symptoms
• Cognitive and physical findings
• Key clinical investigations typically undertaken
• Broad therapeutic approaches
• Natural history and prognosis

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. John Hodges has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.