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1. Introduction
2. Health concerns in the 20th and 21st centuries
3. Different viral infections worldwide
4. Current treatments
5. Drug development considerations for antivirals
6. Innate immune response
7. Different pathogen recognition receptors
8. IFN influences on immune response
9. High conservation degree in IFNalpha subtypes
10. IFN subtypes exhibit variable antiviral potency
11. Type I IFN signaling
12. Global outbreak of SARS
13. Why so virulent?
14. A mouse model of SARS CoV
15. Type I IFN expression profile in infected mice
16. IFN-beta protects A/J mice from MHV-1 infection
17. Inhibition of SARS CoV by IFN
18. Representative chest X-rays in SARS patients
19. Interferon effect on lung pathology
20. O2 saturation over time
21. Interferon prevents HIV spread
22. IFN inhibits HIV infection
23. Coxsackievirus B3
24. IFN gene expression in CVB3 infected mice
25. IFN-beta in patients with cardiomyopathy
26. Influenza
27. Human lung organ model for influenza infection
28. IFN alfacon-1 inhibits H5N1 replication in lung
29. Swain flu
30. IFN treatment inhibits A/WSN/33 H1N1 infection
31. IFN-alpha treatment inhibits influenza replication
32. IFN inhibits influenza replication
33. Post infection IFN alfacon-1 inhibits influenza
34. IFN inhibits pandemic H1N1 replication
35. A pilot study
36. IFNs exhibit different affinities for IFNAR
37. 3 amino acid clusters residues influence activity
38. IFN alfacon-1
39. IFN-alpha-2 interaction with receptor
40. Receptor affinity
41. In silico modeling
42. Strategy for design of nonpeptide mimetics
43. Acknowledgements

Topics Covered

• Emerging and re-emerging virus infections globally
• Time lag before a new vaccine is available during a pandemic
• Antivirals that are pathogen specific lead to viral resistance
• Broad spectrum antivirals needed
• Interferons -alpha -beta are produced in response to all virus infections
• Every cell/tissue will respond to interferon
• Widespread application for all virus infections

Links

Series:

• Cytokines

Categories:

• Biochemistry
• Cell Biology
• Diseases, Disorders & Treatments
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Fish, E. (2011, December 5). Interferons as antivirals: translating basic research into clinical application [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 11, 2020, from https://hstalks.com/bs/2154/.

Publication History

• Published on December 5, 2011

Financial Disclosures

• Prof. Eleanor Fish has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.