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Printable Handouts
Navigable Slide Index
- Introduction
- Rheumatic fever & rheumatic heart disease
- Rheumatic fever (RH)
- Rheumatic heart disease (RHD)
- Questions (1)
- S. pyogenes in vitro colonization
- Streptococcus pyogenes
- Molecular mimicry (1)
- Humoral and cellular immune response
- Genetic susceptibility
- RF/RHD genetic susceptibility markers
- Molecular mimicry (2)
- Specific antigen recognition by T cells (1)
- T lymphocytes and HLA class II molecules
- RHD patients recognize heart proteins
- Heart tissue: Aschoff bodies
- VCAM-1 and recruitment of T lymphocytes
- Heart tissue
- Mitral valve lesions occur by molecular mimicry
- Heart-infiltrating T cell clones, RHD
- Lymphocytes x M protein x HLA
- Cross-reactive intralesional T cell clone
- Mitral valve proteins identification
- Cardiac myosin structure
- Cardiac myosin cross-reactivity patterns
- Peptide alignment
- Specific antigen recognition by T cells (2)
- PBMC-Treg cells: RHD patients vs. healthy
- TREC – T cell receptor excision circles
- TREC quantification
- T lymphocytes repertoire (TCR-VB JB)
- Heart lesions (1)
- Heart lesions (2)
- Questions (2)
- Cytokine production in the heart (1)
- Cytokine production in the heart (2)
- Cross-reactive intralesional T cell clones
- RF/RHD - pathogenesis model
- Chemokines
- Autoimmune process
- Molecular mimicry - T cells
- Conclusions (so far)
- The idea of a vaccine
- Vaccine - is it safe?
- Anti- S. pyogenes vaccine design
- M protein-C-terminal region: T and B epitopes
- PepVac StreptIncor vaccine epitope
- Adhesion/Invasion inhibition
- HLA-class II Tg mice
- Phagocytosis of S. pyogenes through antibodies
- Current status
- Summary
- Heart Institute, University of São Paulo, Brazil
- Acknowledgments
Topics Covered
- Autoimmunity in humans
- Infectious agents can induce breakage of tolerance to self to trigger & maintain autoimmune disease
- Rheumatic Fever & Rheumatic Heart Disease (RHD) as paradigms of post-infectious autoimmune disease
- Medical & sociological importance of RHD
- Genes involved in susceptibility
- T cell mediated autoimmunity
- Molecular mimicry
- Role of Th1 cells in human autoimmunity
- How chemokines can drive disease to different site
- Identification of autoimmune vs. anti-infection triggering epitopes
- Vaccine development to avoid infections & autoimmune disease
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Kalil, J. (2019, June 30). Rheumatic fever: a model of a post-infectious autoimmune disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/AROS8692.Export Citation (RIS)
Publication History
Financial Disclosures
- Commercial/Financial matters disclosed are: Inventor of the vaccine against Streptococcus. As inventor the speaker might have the right to possible royalties.
A selection of talks on Immunology
Transcript
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0:00
I'm Jorge Kalil, I am a Professor and Head of Division of
Clinical Immunology and Allergy at the School of Medicine University of Sao Paulo.
I'm also Head of the Laboratory of Immunology at the Heart Institute,
(InCor) at the same institution.
What we're going to talk today is on "Rheumatic Fever".
That is a model of post infectious autoimmune disease.
Actually, it's perhaps one of the best if not the best model.
How to study post infectious autoimmune disease in men.
0:34
So rheumatic fever occurs after an infection of
the throat of Streptococcus pyogenes a very common infection in children.
These people that are susceptible,
and in a survey it seems that three to four percent of the people would
be susceptible to the disease if not treated the sore throat.
They will appear with polyarthritis.
They can have the erythema marginatum,
subcutaneous nodules Sydenham's chorea,
but actually what they have is a carditis. And this carditis
may evolve in the future eventually to rheumatic heart disease.
That means that this carditis will bring to
the lesions on the valves that would be permanent.
This occurs in one third of the people that have rheumatic fever and have not being treated.
1:30
So rheumatic fever as I've mentioned,
has an universal incidents to three to four percent of
children between five to 16 years if the sore throats are not treated.
The rheumatic heart disease occuring
one third to 45 percent of all the patients that had rheumatic fever.
There is an enormous number of cases in the world.
We estimate that there are
around 616 million cases of pharyngitis due to group A Streptococcus,
and also have something like 16 million cases of rheumatic heart disease.
These account for more than 200 thousand deaths per year.