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1. Introduction
2. Rheumatic fever & rheumatic heart disease
3. Rheumatic fever (RH)
4. Rheumatic heart disease (RHD)
5. Questions (1)
6. S. pyogenes in vitro colonization
7. Streptococcus pyogenes
8. Molecular mimicry (1)
9. Humoral and cellular immune response
10. Genetic susceptibility
11. RF/RHD genetic susceptibility markers
12. Molecular mimicry (2)
13. Specific antigen recognition by T cells (1)
14. T lymphocytes and HLA class II molecules
15. RHD patients recognize heart proteins
16. Heart tissue: Aschoff bodies
17. VCAM-1 and recruitment of T lymphocytes
18. Heart tissue
19. Mitral valve lesions occur by molecular mimicry
20. Heart-infiltrating T cell clones, RHD
21. Lymphocytes x M protein x HLA
22. Cross-reactive intralesional T cell clone
23. Mitral valve proteins identification
24. Cardiac myosin structure
25. Cardiac myosin cross-reactivity patterns
26. Peptide alignment
27. Specific antigen recognition by T cells (2)
28. PBMC-Treg cells: RHD patients vs. healthy
29. TREC – T cell receptor excision circles
30. TREC quantification
31. T lymphocytes repertoire (TCR-VB JB)
32. Heart lesions (1)
33. Heart lesions (2)
34. Questions (2)
35. Cytokine production in the heart (1)
36. Cytokine production in the heart (2)
37. Cross-reactive intralesional T cell clones
38. RF/RHD - pathogenesis model
39. Chemokines
40. Autoimmune process
41. Molecular mimicry - T cells
42. Conclusions (so far)
43. The idea of a vaccine
44. Vaccine - is it safe?
45. Anti- S. pyogenes vaccine design
46. M protein-C-terminal region: T and B epitopes
47. PepVac StreptIncor vaccine epitope
48. Adhesion/Invasion inhibition
49. HLA-class II Tg mice
50. Phagocytosis of S. pyogenes through antibodies
51. Current status
52. Summary
53. Heart Institute, University of São Paulo, Brazil
54. Acknowledgments

Topics Covered

• Autoimmunity in humans
• Infectious agents can induce breakage of tolerance to self to trigger & maintain autoimmune disease
• Rheumatic Fever & Rheumatic Heart Disease (RHD) as paradigms of post-infectious autoimmune disease
• Medical & sociological importance of RHD
• Genes involved in susceptibility
• T cell mediated autoimmunity
• Molecular mimicry
• Role of Th1 cells in human autoimmunity
• How chemokines can drive disease to different site
• Identification of autoimmune vs. anti-infection triggering epitopes
• Vaccine development to avoid infections & autoimmune disease

Links

Series:

• Autoimmunity

Categories:

• Clinical Medicine
• Diseases, Disorders & Treatments
• Genetics & Epigenetics
• Immunology
• Microbiology

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation
• Infectious Diseases
• Vaccines

Talk Citation

Kalil, J. (2019, June 30). Rheumatic fever: a model of a post-infectious autoimmune disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 23, 2019, from https://hstalks.com/bs/214/.

Publication History

• Published on October 1, 2007
• Updated on June 30, 2019

Financial Disclosures

• Commercial/Financial matters disclosed are: Inventor of the vaccine against Streptococcus. As inventor the speaker might have the right to possible royalties.