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Navigable Slide Index
- Introduction
- Molecular redundancy
- Redundant molecules replace disrupted genes
- Genomic structure of the CD44 molecule
- CD44 - alternative splicing
- CD44 ligands
- Dr. Lora Eshkar Sebban
- CD44 functions
- The three steps model of Dr. Springer
- Rolling and migration of CD44-positive cells
- The migration process
- Anti-CD44 mAbs reduce pathological activities
- Anti-CD44 mAbs reduce diabetogenic activity
- Anti-CD44 mAbs reduce arthritic activity
- Generation of CIA model experimental protocol
- In-vivo efficacy in CIA model
- The CD44-dependency of CIA
- CIA is a CD44-dependent disease
- Effect of type 2 collagen injection
- CD44 DNA analysis of CD44-deficient mice
- Flow cytometry: CD44-deficient mice spleen cells
- Sensitivity to CIA: CD44-knockout vs. WT mice
- Histopathology of joints from CD44+/+ and -/- mice
- Photo imaging of histochemical staining revealed
- CD44-deficient mice: hyaluronic acid accumulation
- Anti-CD44 mAb inhibits CIA in WT DBA/1 mice
- Support of collagen-induced arthritis in mice
- Inhibition of CIA by hyaluronidase in WT mice
- Inhibition of CIA in WT and CD44-K/O mice
- CD44-deficient spleen cells bind to HA
- HA-binding protein compensates for CD44 in mice
- The HA binding protein that compensates for CD44
- RHAMM: receptor for hyaluronan-mediated motility
- RHAMM reagents
- RHAMM regulation in CD44-deficient mice (1)
- RHAMM regulation in CD44-deficient mice (2)
- Transwell migration assay
- Spleen cells migration from CD44-deficient mice
- Anti-RHAMM inhibits mice spleen cells migration
- Anti-RHAMM mAb and soluble RHAMM inhibit CIA
- CD44 affect the disease activity
- CD44 deletion affect embryonic development
- RHAMM regulation after CD44 genetic deletion
- RHAMM functions
- Interpretation of the redundancy mechanism
- Disease-specific CD44 (1)
- Disease-specific CD44 (2)
- Exploring CD44 isoforms
- Genomic sequence of: V4/V5 junction, CD44vRA
- Single amino acid exchange and proteins function
- Levels of CD44vRA Abs in mice splenocytes
- Binding F8:33 anti-CD44 mAb to synovial cells
- Synovial fluid cells from an RA and OA patient
- F8:33 anti-CD44vRA mAb bindings
- Does anti-CD44vRA Ab promote apoptosis?
- Anti-CD44vRA mAb induces apoptosis in RA (1)
- Anti-CD44vRA mAb induces apoptosis in RA (2)
- Disease-specific CD44
- Conclusions
- Acknowledgements
- Albert Einstein's wisdom...
- References
- References
Topics Covered
- CD44 and RHAMM (receptor for hyaluronan-mediated motility) are cell adhesion and cell homing receptors
- Cell migration
- Generation of different CD44 isoforms
- RHAMM also supports cell motility and is engaged in intracellular signalling
- Collagen-induced arthritis and type 1 diabetes are CD44-dependent pathologies
- Molecular redundancy
- CD44 targeting by anti-CD44 mAb may eradicate not only malignant cells and destructive inflammatory cells but also CD44-expressing normal cells which are committed to physiological functions
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Talk Citation
Naor, D. (2017, November 28). CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 5, 2024, from https://doi.org/10.69645/SZIG6778.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Naor has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation
A selection of talks on Immunology & Inflammation
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