• Advances in the Understanding of Etiology (I)
• 30 min
  1. Infection and autoimmunity: a two-way relationship

  • Dr. Ricard Cervera
• 35 min
  2. Autoimmunity and atherosclerosis

  • Prof. Johan Frostegard
• 47 min
  3. Endothelium and autoimmunity

  • Prof. Pier Luigi Meroni
• Advances in the Understanding of Etiology (II)
• 22 min
  4. Prolactin has a pathogenic role in systemic lupus erythematosus

  • Prof. Luis Jara-Quezada
• 44 min
  5. Sjögren's syndrome: current knowledge and future prospects

  • Prof. Athanasios G. Tzioufas
• 51 min
  6. Genetic and environmental triggers of autoimmune thyroid diseases

  • Prof. Yaron Tomer
• Advances in Pathogenesis and Clinical Manifestation
• 38 min
  7. The catastrophic antiphospholipid syndrome and the microangiopathic antiphospholipid syndrome

  • Prof. Ronald Asherson
• 20 min
  8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes

  • Dr. Luís Eduardo Coelho Andrade
• 34 min
  9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens

  • Dr. Luís Eduardo Coelho Andrade
• 43 min
  10. What causes primary biliary cholangitis?

  • Dr. M. Eric Gershwin
• 30 min
  11. Capillaroscopy in autoimmune rheumatic diseases

  • Prof. Maurizio Cutolo
• Advances in Diagnostic Methodologies (I)
• 26 min
  12. The past, present & future of ANA testing: history and challenges of ANA

  • Prof. Marvin J. Fritzler
• 33 min
  13. The past, present & future of ANA testing: changing bandwidth and future of ANA

  • Prof. Marvin J. Fritzler
• 36 min
  14. Diagnostic methods in autoimmunity

  • Mr. Steven Binder
• 24 min
  15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1

  • Prof. Chaim Putterman
  • Dr. Noa Schwartz
• 28 min
  16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2

  • Prof. Chaim Putterman
  • Dr. Noa Schwartz
• 48 min
  17. Novel aspects of systemic sclerosis

  • Prof. Gabriele Valentini
• Advances in Diagnostic Methodologies (II)
• 46 min
  18. An update on the multiple faces of celiac disease

  • Prof. Aaron Lerner
• 23 min
  19. Protective autoantibodies

  • Prof. Elias Toubi
• 32 min
  20. CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation

  • Prof. David Naor
• 44 min
  21. Rheumatic fever: a model of a post-infectious autoimmune disease

  • Prof. Jorge Kalil
• Treatments of autoimmune diseases
• 38 min
  22. Intravenous immunoglobulins: clinical evidence

  • Prof. Shaye Kivity
• Latest Developments in the Field
• 26 min
  23. Adjuvants and autoimmunity

  • Dr. Eitan Israeli
• 46 min
  24. Antiphospholipid syndrome (APS): from pathogenesis to treatment

  • Prof. Roger Levy
• 24 min
  25. Vitamin D and autoimmunity

  • Dr. Shir Azrielant
• 28 min
  26. Pregnancy in rheumatic diseases

  • Prof. Pier Luigi Meroni
• Archived Lectures *These may not cover the latest advances in the field
• 47 min
  27. Pathogenic mechanisms of autoantibodies

  • Prof. Cees Kallenberg
• 41 min
  28. B lymphocytes on the frontline of autoimmunity

  • Prof. Pierre Youinou
• 42 min
  29. Apoptotic cell clearance deficiency

  • Prof. Martin Herrmann
• 34 min
  30. Auto-antibodies as predictors of autoimmune disease

  • Dr. Nicola Bizzaro
• 46 min
  31. Innate immunity and natural autoantibodies

  • Prof. Luc Mouthon
• 45 min
  32. Accelerated atherosclerosis in autoimmune rheumatic disease

  • Dr. Andrea Doria
• 47 min
  33. Pregnancy in autoimmune rheumatic diseases

  • Prof. Angela Tincani
• 42 min
  34. Pulmonary hypertension in the connective tissue disease pathogenesis, clinical features and therapeutic options in 2006

  • Prof. Ronald Asherson
• 39 min
  35. Use of algorithms for high quality diagnostics and handling of patients with autoimmune rheumatic diseases

  • Dr. Allan Wiik
• 24 min
  36. Immunologic mechanisms in systemic lupus erythematosus

  • Prof. Kok-Yong Fong
• 23 min
  37. Osteoimmunology

  • Prof. João Eurico Fonseca
  • Ms. Joana Caetano-Lopes
• 43 min
  38. ANCA-associated systemic vasculitides

  • Prof. Loic Guillevin
• 23 min
  39. The common origin for diverse autoimmune diseases

  • Prof. Juan-Manuel Anaya
• 76 min
  40. Anti-cytokine therapy in rheumatoid arthritis

  • Prof. Piercarlo Sarzi-Puttini
• 40 min
  41. Sjogren's syndrome: autoimmune epithelitis

  • Prof. Haralampos Moutsopoulos
• 31 min
  42. Vitamin D and autoimmunity

  • Dr. Howard Amital
• 25 min
  43. Intravenous immunoglobulins: myth and reality

  • Prof. Zera Tellier

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Self -tolerance prevents autoimmunity
3. Maintaining self tolerance
4. SLE
5. Rheumatoid arthritis (RA)
6. Multiple sclerosis (MS)
7. Protection against autoimmune diseases
8. Complement is protective against autoimmunity
9. SAP is protective against autoimmunity
10. Complement causes death of autoreactive cells
11. Complement mediates tolerization
12. Studies in mice
13. Anti-MBP autoreactive T cells
14. Autoreactive T cells are maintained in blood
15. Autoreactive T cells induce neuronal damage
16. MBP injection induces autoreactive T cells
17. Autoreactive T cells are protective
18. MBP-specific Th1 cells induce neuroprotection
19. Passive transfer of MP-specific Th1 cells
20. Autoreactive T cells - dual role
21. T reg cells prevent neuroprotection
22. Th1 - balance between protective or destructive
23. Humoral protective autoimmunity
24. Natural antibodies are mostly of IgM
25. Natural protective Abs
26. Strong activation of C1q - C4
27. Early and late response to pathogens
28. IgM NA are critical for protection against infection
29. Role of natural autoantibodies in autoimmunity
30. Non-specific low affinity NAA against self-Ags
31. Mechanism for IgM protection in autoimmunity
32. NAA are protective against autoimmune diseases
33. IgM are beneficial in lupus
34. IgM NAA protect against autoimmunity
35. IgM anti-dsDNA is beneficial in SLE
36. IgM are protective due to minimal deposition
37. IgM enhance IC clearance via compliment receptor
38. Protective IgM control self-reactive IgG in SLE
39. NAA downregulate self-reactive T cells
40. IgM are needed for autoimmunity prevention
41. The timing of exposure to NIgM is important
42. IgM anti-RF is protective in SLE
43. Suggested mechanisms for a protective role for RF
44. IgM in rheumatoid arthritis
45. NAA in IVIG
46. Anti-Id Abs in IVIG
47. Anti-Id Abs aid to immunocomplex clearance
48. Protective antibodies in IVIG - modes of action
49. Protective autoimmunity in cancer
50. Vitiligo auto-Abs reduce lung metastases
51. Human IgM induce cancer cells apoptosis
52. Mechanisms of apoptosis induction by IgM
53. A role for IVIM?
54. Naturally occurring protective IgG Abs
55. Anti-CTLA4 Abs
56. Summary

Topics Covered

• Autoimmunity
• Tolerance
• T regulatory cells
• Protective cellular autoimmunity
• Protective humoral autoimmunity
• Protective autoimmunity in autoimmune diseases and cancer

Links

Series:

• Autoimmunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 11, 2017

Financial Disclosures

• Prof. Elias Toubi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.