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1. Introduction
2. Self -tolerance prevents autoimmunity
3. Maintaining self tolerance
4. SLE
5. Rheumatoid arthritis (RA)
6. Multiple sclerosis (MS)
7. Protection against autoimmune diseases
8. Complement is protective against autoimmunity
9. SAP is protective against autoimmunity
10. Complement causes death of autoreactive cells
11. Complement mediates tolerization
12. Studies in mice
13. Anti-MBP autoreactive T cells
14. Autoreactive T cells are maintained in blood
15. Autoreactive T cells induce neuronal damage
16. MBP injection induces autoreactive T cells
17. Autoreactive T cells are protective
18. MBP-specific Th1 cells induce neuroprotection
19. Passive transfer of MP-specific Th1 cells
20. Autoreactive T cells - dual role
21. T reg cells prevent neuroprotection
22. Th1 - balance between protective or destructive
23. Humoral protective autoimmunity
24. Natural antibodies are mostly of IgM
25. Natural protective Abs
26. Strong activation of C1q - C4
27. Early and late response to pathogens
28. IgM NA are critical for protection against infection
29. Role of natural autoantibodies in autoimmunity
30. Non-specific low affinity NAA against self-Ags
31. Mechanism for IgM protection in autoimmunity
32. NAA are protective against autoimmune diseases
33. IgM are beneficial in lupus
34. IgM NAA protect against autoimmunity
35. IgM anti-dsDNA is beneficial in SLE
36. IgM are protective due to minimal deposition
37. IgM enhance IC clearance via compliment receptor
38. Protective IgM control self-reactive IgG in SLE
39. NAA downregulate self-reactive T cells
40. IgM are needed for autoimmunity prevention
41. The timing of exposure to NIgM is important
42. IgM anti-RF is protective in SLE
43. Suggested mechanisms for a protective role for RF
44. IgM in rheumatoid arthritis
45. NAA in IVIG
46. Anti-Id Abs in IVIG
47. Anti-Id Abs aid to immunocomplex clearance
48. Protective antibodies in IVIG - modes of action
49. Protective autoimmunity in cancer
50. Vitiligo auto-Abs reduce lung metastases
51. Human IgM induce cancer cells apoptosis
52. Mechanisms of apoptosis induction by IgM
53. A role for IVIM?
54. Naturally occurring protective IgG Abs
55. Anti-CTLA4 Abs
56. Summary

Topics Covered

• Autoimmunity
• Tolerance
• T regulatory cells
• Protective cellular autoimmunity
• Protective humoral autoimmunity
• Protective autoimmunity in autoimmune diseases and cancer

Links

Series:

• Autoimmunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 11, 2017

Financial Disclosures

• Prof. Elias Toubi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.