• Microbiota: Agents for Health and Disease
• 38 min
  1. Introduction to microbiota: agents for health and disease

  • Prof. B. Brett Finlay
• The Human Microbiota
• 86 min
  2. The human microbiome project

  • Prof. George Weinstock
• 56 min
  3. The human indigenous microbiota

  • Prof. David Relman
• 46 min
  4. Gut microbiota, chronic inflammation and metabolic syndrome

  • Prof. Andrew Gewirtz
• Microbiota and Disease
• 30 min
  5. Role of the microbiota in asthma

  • Prof. B. Brett Finlay
• 45 min
  6. Disappearing microbiota and human metabolic health

  • Prof. Martin Blaser
• 41 min
  7. The microbiota in the development of colitis due to Clostridium difficile infection

  • Dr. Vincent Young
• 55 min
  8. Gram+ bacterial microbiota - Yin & Yang of infectious disease

  • Prof. P. Patrick Cleary
• 50 min
  9. Salmonella diarrhea: contributions from the microbiota, the pathogen and the host

  • Prof. Dr. Wolf-Dietrich Hardt
• 45 min
  10. Paneth cells, antimicrobial peptides and the regulation of the intestinal microbiota

  • Dr. Nita Salzman
• 35 min
  11. Microbiota and oral disease

  • Prof. Dennis Cvitkovitch
• 34 min
  12. Microbiota and inflammatory bowel disease

  • Prof. Janet Jansson
• Host Responses
• 56 min
  13. The role of the enteric microbiota in T cell differentiation

  • Prof. Dan Littman
• 37 min
  14. Nod proteins in mucosal defense against bacteria: implications for Crohn's disease

  • Dr. Stephen Girardin
• 45 min
  15. Intestinal microbiota and the brain-gut axis

  • Prof. Stephen Collins
• 40 min
  16. Enteric pathogens-microbiota-host inter-kingdom chemical interactions

  • Prof. Vanessa Sperandio
• Preventatives and Therapeutics
• 42 min
  17. Probiotics

  • Dr. Gregor Reid
• Archived Lectures *These may not cover the latest advances in the field
• 58 min
  18. A new frontier in biology: deciphering the molecular language of symbiosis

  • Prof. Margaret McFall-Ngai
• 56 min
  19. Probiotics and prebiotics

  • Prof. Glenn Gibson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Ilya Mechnikov
3. Host-mediated detection of microbes
4. The nod-like receptor family
5. Nod1 and Nod2
6. Nod1 is a sensor for a peptidoglycan (1)
7. Nod1 is a sensor for a peptidoglycan (2)
8. Nod1 is a sensor for a peptidoglycan (3)
9. Nod2 is a sensor for a peptidoglycan
10. Nod1 & Nod2 recognize bacterial peptidoglycan
11. Role of Nod1 in infected intestinal epithelial cells
12. Nod1 and Nod2 are intracellular PRMs
13. How Nod ligands get access to host cytosol
14. Muramyl peptides - activity requires internalization
15. Nod1 ligands: structure and activity (1)
16. Nod1 ligands: structure and activity (2)
17. Nod1 ligands escape the endocytic pathway
18. Model - how Nod ligands enter the host cytosol
19. SLC15A4 is a transporter for Nod1 ligands
20. Upregulation of SLC15A4 in disease
21. Nod2 and Crohn's disease
22. Nod-like receptor & auto-inflammatory disorders
23. Expression of functional Nod2 in epithelial cells
24. The 3020insC frame-shift mutation of Nod2 (1)
25. The 3020insC frame-shift mutation of Nod2 (2)
26. Other Crohn's disease associated Nod2 mutations
27. Models explaining the Nod2 loss & CD paradox
28. Loss of antimicrobial activity
29. MDP triggers antimicrobial peptide secretion
30. Defective induction of defensins
31. Decreased production of NO
32. Production of antimicrobial ROS
33. Nod2 mutation in CD-gain of function mutation (1)
34. Nod2 mutation in CD-gain of function mutation (2)
35. Negative regulation of Th1 responses by Nod2
36. Defective Nod2 targeting to plasma membrane
37. Defective polarization of Th2 immune responses
38. More recent models - autophagy
39. ATG16L1 and Crohn's disease (1)
40. ATG16L1 and Crohn's disease (2)
41. ATG16L1 and Crohn's disease (3)
42. Bacterial autophagy
43. Nod2fs cells fail to direct autophagy
44. Nod2 brings ATG16L1 to the membrane
45. Nod1/Nod2 direct autophagy to bacterial entry site
46. More recent models- the IL-17/IL-22 axis
47. Delayed histopathology in Nod1/2 DKO mice
48. Early IL-17 responses are Nod1/2 dependent (1)
49. Early IL-17 responses are Nod1/2 dependent (2)
50. Specific cells produce IL-17/22 early
51. Lack of early Th17 response NOD1/2 KNO mice
52. Working model
53. General conclusions

Topics Covered

• Innate immunity
• Host detection of intracellular bacterial pathogens by Nod-like receptors
• Dysregulation of intestinal immune control of bacteria
• Crohn's disease

Links

Series:

• Microbiota

Categories:

• Clinical Practice
• Microbiology

Talk Citation

Publication History

• Published on September 27, 2011

Financial Disclosures

• Dr. Stephen Girardin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.