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- Advances in the Understanding of Etiology (I)
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1. Infection and autoimmunity: a two-way relationship
- Dr. Ricard Cervera
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2. Autoimmunity and atherosclerosis
- Prof. Johan Frostegard
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3. Endothelium and autoimmunity
- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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4. Prolactin has a pathogenic role in systemic lupus erythematosus
- Prof. Luis Jara-Quezada
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5. Sjögren's syndrome: current knowledge and future prospects
- Prof. Athanasios G. Tzioufas
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6. Genetic and environmental triggers of autoimmune thyroid diseases
- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
- Dr. Luís Eduardo Coelho Andrade
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9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens
- Dr. Luís Eduardo Coelho Andrade
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10. What causes primary biliary cholangitis?
- Dr. M. Eric Gershwin
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11. Capillaroscopy in autoimmune rheumatic diseases
- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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12. The past, present & future of ANA testing: history and challenges of ANA
- Prof. Marvin J. Fritzler
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13. The past, present & future of ANA testing: changing bandwidth and future of ANA
- Prof. Marvin J. Fritzler
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14. Diagnostic methods in autoimmunity
- Mr. Steven Binder
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15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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17. Novel aspects of systemic sclerosis
- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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18. An update on the multiple faces of celiac disease
- Prof. Aaron Lerner
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19. Protective autoantibodies
- Prof. Elias Toubi
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21. Rheumatic fever: a model of a post-infectious autoimmune disease
- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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22. Intravenous immunoglobulins: clinical evidence
- Prof. Shaye Kivity
- Latest Developments in the Field
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23. Adjuvants and autoimmunity
- Dr. Eitan Israeli
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24. Antiphospholipid syndrome (APS): from pathogenesis to treatment
- Prof. Roger Levy
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25. Vitamin D and autoimmunity
- Dr. Shir Azrielant
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26. Pregnancy in rheumatic diseases
- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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27. Pathogenic mechanisms of autoantibodies
- Prof. Cees Kallenberg
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28. B lymphocytes on the frontline of autoimmunity
- Prof. Pierre Youinou
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29. Apoptotic cell clearance deficiency
- Prof. Martin Herrmann
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30. Auto-antibodies as predictors of autoimmune disease
- Dr. Nicola Bizzaro
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31. Innate immunity and natural autoantibodies
- Prof. Luc Mouthon
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32. Accelerated atherosclerosis in autoimmune rheumatic disease
- Dr. Andrea Doria
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33. Pregnancy in autoimmune rheumatic diseases
- Prof. Angela Tincani
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36. Immunologic mechanisms in systemic lupus erythematosus
- Prof. Kok-Yong Fong
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37. Osteoimmunology
- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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38. ANCA-associated systemic vasculitides
- Prof. Loic Guillevin
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39. The common origin for diverse autoimmune diseases
- Prof. Juan-Manuel Anaya
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40. Anti-cytokine therapy in rheumatoid arthritis
- Prof. Piercarlo Sarzi-Puttini
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41. Sjogren's syndrome: autoimmune epithelitis
- Prof. Haralampos Moutsopoulos
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42. Vitamin D and autoimmunity
- Dr. Howard Amital
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43. Intravenous immunoglobulins: myth and reality
- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Atherosclerosis (ATS)
- Pathogenetic steps in atherosclerosis
- Triggers and common pathway in atherosclerosis
- Features of innate and adaptive immunity in ATS
- Innate immunity factors involved in inflammatory
- CRP distribution within the atherosclerotic plaque
- CRP is a predictor of cardiovascular diseases
- Unstable carotid plaque (CARS)
- CD4+CD28null cells are expanded in angina
- CD4+CD28null lymphocytes are pro inflammatory
- CD4+CD28null in rheumatoid arthritis patients
- CD4+CD28null cells and increased IMT
- Atherosclerosis and autoimmunity
- Role of oxLDL in foam cells formation
- Anti-oxLDL and atherosclerosis
- Protective and pathogenetic anti-oxLDL
- Antiphospholipid antibodies
- Structure of beta-2GPI
- Surface charge and binding of beta-2GPI
- Beta-2GPI as a target for APL Abs
- Formation of oxLDL and beta-2GPI complex
- oxLDL/beta-2GPI as an inflammation marker
- The role of beta-2GPI in atherogenesis
- beta-2GPI localization in atherosclerotic plaques
- Immunization with beta-2GPI
- Antiphospholipid antibodies in ATS patients
- Example: protective role of anti-phospholipid Abs
- Human heat-shock proteins (HSP)
- Anti-heat shock protein (HSP) 60/65 antibodies
- Enhanced ATS and associated factors in ARD
- Atherosclerosis in RA - historical view
- Coronary artery disease in RA patients
- Coronary artery disease in SLE patients
- Incidence of MI in SLE patients
- Risk factors for atherosclerosis in SLE
- Non-invasive techniques for detection of ATS
- Duplex ultrasonography
- Intima-media thickness (IMT) in RA patients
- Risk factors for cardiovascular events
- Parallelism between RA and atherosclerosis
- Carotid ultrasound studies in SLE
- Traditional and other metabolic risk factors for ATS
- Cardiovascular risk in lupus
- Novel risk factors for atherosclerosis
- CRP and subclinical atherosclerosis in SLE
- The relationship between autoantibodies and ATS
- Subclinical atherosclerosis in SLE: study design
- M-IMT and IgG anti-oxLDL levels - correlation
- Mid conclusions
- Questions which should be addressed
- Correlates of accelerated atherosclerosis in SLE
- Who are at highest risk for accelerated ATS?
- Risk factors for carotid plaques in SLE
- 78 SLE patients
- PRD cumulative dosage in different patients
- PRD dosage - adjusted for traditional risk factors
- The bimodal mortality pattern of SLE
- Long-term prognosis in SLE
- Long-term prognosis in severe vs. mild SLE
- Take home message
- Conclusions
- Role of the endothelium in vascular homoeostasis
- Assessment of endothelial function
- Ultrasonography of brachial artery
- Endothelial dysfunction as predictor of CV events
- Endothelial dysfunction in autoimmune diseases
- Why does this correlation exist?
- Distant effects of local vascular inflammation
- Acknowledgments
Topics Covered
- Immunoinflammatory mechanisms involved in atherosclerosis
- Autoantibodies and atherosclerosis
- Clinical and subclinical atherosclerosis in rheumatoid arthritis
- Clinical and subclinical atherosclerosis in systemic lupus erythematosus
- Traditional and non-traditional risk factors for atherosclerosis in autoimmune rheumatic diseases
- Assessment of endothelial function in autoimmune rheumatic diseases
- Endothelial dysfunction in autoimmune rheumatic diseases
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Doria, A. (2007, October 1). Accelerated atherosclerosis in autoimmune rheumatic disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 14, 2024, from https://doi.org/10.69645/AYNB6698.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Andrea Doria has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.