• Advances in the Understanding of Etiology (II)
• 22 min
  1. Prolactin has a pathogenic role in systemic lupus erythematosus

  • Prof. Luis Jara-Quezada
• 44 min
  2. Sjögren's syndrome: current knowledge and future prospects

  • Prof. Athanasios G. Tzioufas
• 51 min
  3. Genetic and environmental triggers of autoimmune thyroid diseases

  • Prof. Yaron Tomer
• Advances in Pathogenesis and Clinical Manifestation
• 20 min
  4. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes

  • Dr. Luís Eduardo Coelho Andrade
• 34 min
  5. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens

  • Dr. Luís Eduardo Coelho Andrade
• 43 min
  6. What causes primary biliary cholangitis?

  • Dr. M. Eric Gershwin
• Advances in Diagnostic Methodologies (I)
• 26 min
  7. The past, present & future of ANA testing: history and challenges of ANA

  • Prof. Marvin J. Fritzler
• 33 min
  8. The past, present & future of ANA testing: changing bandwidth and future of ANA

  • Prof. Marvin J. Fritzler
• 36 min
  9. Diagnostic methods in autoimmunity

  • Mr. Steven Binder
• 24 min
  10. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1

  • Prof. Chaim Putterman
  • Dr. Noa Schwartz
• 28 min
  11. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2

  • Prof. Chaim Putterman
  • Dr. Noa Schwartz
• 48 min
  12. Novel aspects of systemic sclerosis

  • Prof. Gabriele Valentini
• Advances in Diagnostic Methodologies (II)
• 46 min
  13. An update on the multiple faces of celiac disease

  • Prof. Aaron Lerner
• 44 min
  14. Rheumatic fever: a model of a post-infectious autoimmune disease

  • Prof. Jorge Kalil
• Treatments of autoimmune diseases
• 38 min
  15. Intravenous immunoglobulins: clinical evidence

  • Prof. Shaye Kivity
• Latest Developments in the Field
• 26 min
  16. Adjuvants and autoimmunity

  • Dr. Eitan Israeli
• 46 min
  17. Antiphospholipid syndrome (APS): from pathogenesis to treatment

  • Prof. Roger Levy
• 24 min
  18. Vitamin D and autoimmunity

  • Dr. Shir Azrielant
• 28 min
  19. Pregnancy in rheumatic diseases

  • Prof. Pier Luigi Meroni
• Archived Lectures *These may not cover the latest advances in the field
• 47 min
  20. Pathogenic mechanisms of autoantibodies

  • Prof. Cees Kallenberg
• 41 min
  21. B lymphocytes on the frontline of autoimmunity

  • Prof. Pierre Youinou
• 42 min
  22. Apoptotic cell clearance deficiency

  • Prof. Martin Herrmann
• 34 min
  23. Auto-antibodies as predictors of autoimmune disease

  • Dr. Nicola Bizzaro
• 46 min
  24. Innate immunity and natural autoantibodies

  • Prof. Luc Mouthon
• 45 min
  25. Accelerated atherosclerosis in autoimmune rheumatic disease

  • Dr. Andrea Doria
• 47 min
  26. Pregnancy in autoimmune rheumatic diseases

  • Prof. Angela Tincani
• 42 min
  27. Pulmonary hypertension in the connective tissue disease pathogenesis, clinical features and therapeutic options in 2006

  • Prof. Ronald Asherson
• 39 min
  28. Use of algorithms for high quality diagnostics and handling of patients with autoimmune rheumatic diseases

  • Dr. Allan Wiik
• 24 min
  29. Immunologic mechanisms in systemic lupus erythematosus

  • Prof. Kok-Yong Fong
• 23 min
  30. Osteoimmunology

  • Prof. João Eurico Fonseca
  • Ms. Joana Caetano-Lopes
• 43 min
  31. ANCA-associated systemic vasculitides

  • Prof. Loic Guillevin
• 23 min
  32. The common origin for diverse autoimmune diseases

  • Prof. Juan-Manuel Anaya
• 76 min
  33. Anti-cytokine therapy in rheumatoid arthritis

  • Prof. Piercarlo Sarzi-Puttini
• 40 min
  34. Sjogren's syndrome: autoimmune epithelitis

  • Prof. Haralampos Moutsopoulos
• 31 min
  35. Vitamin D and autoimmunity

  • Dr. Howard Amital
• 25 min
  36. Intravenous immunoglobulins: myth and reality

  • Prof. Zera Tellier
• 38 min
  37. The catastrophic antiphospholipid syndrome and the microangiopathic antiphospholipid syndrome

  • Prof. Ronald Asherson
• 47 min
  38. Endothelium and autoimmunity

  • Prof. Pier Luigi Meroni
• 30 min
  39. Infection and autoimmunity: a two-way relationship

  • Dr. Ricard Cervera
• 35 min
  40. Autoimmunity and atherosclerosis

  • Prof. Johan Frostegard
• 30 min
  41. Capillaroscopy in autoimmune rheumatic diseases

  • Prof. Maurizio Cutolo
• 23 min
  42. Protective autoantibodies

  • Prof. Elias Toubi
• 32 min
  43. CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation

  • Prof. David Naor

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Host defense mechanisms
3. Innate immunity: first line of defense
4. Physiological autoreactivity
5. Autoimmunity
6. Immunological tolerance
7. Self-reactive T lymphocytes in healthy individuals
8. Self-reactive T lymphocytes potential mechanisms
9. Self-reactive T lymphocytes control mechanisms
10. Regulatory T lymphocytes
11. Natural autoantibodies
12. Definition
13. Characteristics of natural autoantibodies
14. Target auto-Ags recognition by natural auto-Abs
15. Origin of natural autoantibodies
16. Selection of antibody repertoires (1)
17. Selection of antibody repertoires (2)
18. Negative selection of B lymphocytes
19. Positive selection - central
20. Positive selection - peripheral
21. Positive selection of B1 lymphocytes
22. Sources of autoantigens
23. Quantitative immunoblotting technique
24. Serum IgM reactivities against kidney antigens
25. Analysis of IgM reactivities with different self-Ags
26. IgM reactivities with different proteins
27. Repertoires analysis against stomach Ags (1)
28. IgG reactivity directed against P. aeruginosa Ags
29. Immunological homunculus (1)
30. Receptor editing (1)
31. Receptor editing (2)
32. B cell receptor editing
33. Natural vs. pathogenic autoantibodies
34. The majority of natural Abs are natural auto-Abs
35. Natural and autoimmune-associated auto-Abs
36. IgG autoantibody activity in normal mice
37. IgM autoantibody activity in normal mice
38. Normal IgG reactivities on a panel of self-Ags
39. Autoreactivity in health and disease
40. Repertoires analysis against stomach Ags (2)
41. Repertoires analysis against self-Ags
42. Self reactive IgG repertoires in healthy individuals
43. Myasthenia gravis - purified IgG vs. controls
44. Immunological homunculus (2)
45. Control of natural auto-Abs expression
46. Cryptic autoantibodies
47. IgG reactivities towards different protein extracts
48. IgG directed against stomach antigens
49. Self reactive IgG repertoires in healthy individuals
50. Factors controlling IgG reactivities in whole serum
51. Autologous anti-idiotypic Abs
52. IgG autoantibody activity is controlled by IgM
53. Inhibition of IgG reactivities
54. Antiphospholipid reactivities in heat-treated sera
55. Functions of natural autoantibodies (1)
56. Functions of natural autoantibodies (2)
57. Adaptive humoral immune response
58. Intravenous immunoglobulin (IVIg)
59. Reactivity profile of IVIg with liver antigens
60. Reported reactivities present in IVIg
61. Conclusion

Topics Covered

• Host defense mechanisms
• Innate immunity: first line of defense
• Physiological autoreactivity
• Autoimmunity
• Immunological tolerance
• Self-reactive B and T lymphocytes
• Natural autoantibodies
• Origins of natural autoantibodies
• Selection of antibody repertoires
• Sources of autoantigens
• Receptor editing
• Differences between natural and pathogenic autoantibodies
• Regulatory mechanisms that control the expression of natural autoantibodies
• Functions of natural autoantibodies
• Failure of control mechanisms is responsible for the occurrence of autoimmune diseases

Links

Series:

• Autoimmunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Luc Mouthon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.