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- Advances in the Understanding of Etiology (I)
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1. Infection and autoimmunity: a two-way relationship
- Dr. Ricard Cervera
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2. Autoimmunity and atherosclerosis
- Prof. Johan Frostegard
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3. Endothelium and autoimmunity
- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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4. Prolactin has a pathogenic role in systemic lupus erythematosus
- Prof. Luis Jara-Quezada
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5. Sjögren's syndrome: current knowledge and future prospects
- Prof. Athanasios G. Tzioufas
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6. Genetic and environmental triggers of autoimmune thyroid diseases
- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
- Dr. Luís Eduardo Coelho Andrade
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9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens
- Dr. Luís Eduardo Coelho Andrade
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10. What causes primary biliary cholangitis?
- Dr. M. Eric Gershwin
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11. Capillaroscopy in autoimmune rheumatic diseases
- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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12. The past, present & future of ANA testing: history and challenges of ANA
- Prof. Marvin J. Fritzler
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13. The past, present & future of ANA testing: changing bandwidth and future of ANA
- Prof. Marvin J. Fritzler
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14. Diagnostic methods in autoimmunity
- Mr. Steven Binder
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15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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17. Novel aspects of systemic sclerosis
- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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18. An update on the multiple faces of celiac disease
- Prof. Aaron Lerner
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19. Protective autoantibodies
- Prof. Elias Toubi
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21. Rheumatic fever: a model of a post-infectious autoimmune disease
- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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22. Intravenous immunoglobulins: clinical evidence
- Prof. Shaye Kivity
- Latest Developments in the Field
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23. Adjuvants and autoimmunity
- Dr. Eitan Israeli
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24. Antiphospholipid syndrome (APS): from pathogenesis to treatment
- Prof. Roger Levy
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25. Vitamin D and autoimmunity
- Dr. Shir Azrielant
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26. Pregnancy in rheumatic diseases
- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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27. Pathogenic mechanisms of autoantibodies
- Prof. Cees Kallenberg
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28. B lymphocytes on the frontline of autoimmunity
- Prof. Pierre Youinou
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29. Apoptotic cell clearance deficiency
- Prof. Martin Herrmann
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30. Auto-antibodies as predictors of autoimmune disease
- Dr. Nicola Bizzaro
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31. Innate immunity and natural autoantibodies
- Prof. Luc Mouthon
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32. Accelerated atherosclerosis in autoimmune rheumatic disease
- Dr. Andrea Doria
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33. Pregnancy in autoimmune rheumatic diseases
- Prof. Angela Tincani
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36. Immunologic mechanisms in systemic lupus erythematosus
- Prof. Kok-Yong Fong
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37. Osteoimmunology
- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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38. ANCA-associated systemic vasculitides
- Prof. Loic Guillevin
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39. The common origin for diverse autoimmune diseases
- Prof. Juan-Manuel Anaya
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40. Anti-cytokine therapy in rheumatoid arthritis
- Prof. Piercarlo Sarzi-Puttini
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41. Sjogren's syndrome: autoimmune epithelitis
- Prof. Haralampos Moutsopoulos
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42. Vitamin D and autoimmunity
- Dr. Howard Amital
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43. Intravenous immunoglobulins: myth and reality
- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Host defense mechanisms
- Innate immunity: first line of defense
- Physiological autoreactivity
- Autoimmunity
- Immunological tolerance
- Self-reactive T lymphocytes in healthy individuals
- Self-reactive T lymphocytes potential mechanisms
- Self-reactive T lymphocytes control mechanisms
- Regulatory T lymphocytes
- Natural autoantibodies
- Definition
- Characteristics of natural autoantibodies
- Target auto-Ags recognition by natural auto-Abs
- Origin of natural autoantibodies
- Selection of antibody repertoires (1)
- Selection of antibody repertoires (2)
- Negative selection of B lymphocytes
- Positive selection - central
- Positive selection - peripheral
- Positive selection of B1 lymphocytes
- Sources of autoantigens
- Quantitative immunoblotting technique
- Serum IgM reactivities against kidney antigens
- Analysis of IgM reactivities with different self-Ags
- IgM reactivities with different proteins
- Repertoires analysis against stomach Ags (1)
- IgG reactivity directed against P. aeruginosa Ags
- Immunological homunculus (1)
- Receptor editing (1)
- Receptor editing (2)
- B cell receptor editing
- Natural vs. pathogenic autoantibodies
- The majority of natural Abs are natural auto-Abs
- Natural and autoimmune-associated auto-Abs
- IgG autoantibody activity in normal mice
- IgM autoantibody activity in normal mice
- Normal IgG reactivities on a panel of self-Ags
- Autoreactivity in health and disease
- Repertoires analysis against stomach Ags (2)
- Repertoires analysis against self-Ags
- Self reactive IgG repertoires in healthy individuals
- Myasthenia gravis - purified IgG vs. controls
- Immunological homunculus (2)
- Control of natural auto-Abs expression
- Cryptic autoantibodies
- IgG reactivities towards different protein extracts
- IgG directed against stomach antigens
- Self reactive IgG repertoires in healthy individuals
- Factors controlling IgG reactivities in whole serum
- Autologous anti-idiotypic Abs
- IgG autoantibody activity is controlled by IgM
- Inhibition of IgG reactivities
- Antiphospholipid reactivities in heat-treated sera
- Functions of natural autoantibodies (1)
- Functions of natural autoantibodies (2)
- Adaptive humoral immune response
- Intravenous immunoglobulin (IVIg)
- Reactivity profile of IVIg with liver antigens
- Reported reactivities present in IVIg
- Conclusion
Topics Covered
- Host defense mechanisms
- Innate immunity: first line of defense
- Physiological autoreactivity
- Autoimmunity
- Immunological tolerance
- Self-reactive B and T lymphocytes
- Natural autoantibodies
- Origins of natural autoantibodies
- Selection of antibody repertoires
- Sources of autoantigens
- Receptor editing
- Differences between natural and pathogenic autoantibodies
- Regulatory mechanisms that control the expression of natural autoantibodies
- Functions of natural autoantibodies
- Failure of control mechanisms is responsible for the occurrence of autoimmune diseases
Talk Citation
Mouthon, L. (2007, October 1). Innate immunity and natural autoantibodies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 2, 2024, from https://doi.org/10.69645/SSAB3074.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Luc Mouthon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.