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1. Introduction
2. Host defense mechanisms
3. Innate immunity: first line of defense
4. Physiological autoreactivity
5. Autoimmunity
6. Immunological tolerance
7. Self-reactive T lymphocytes in healthy individuals
8. Self-reactive T lymphocytes potential mechanisms
9. Self-reactive T lymphocytes control mechanisms
10. Regulatory T lymphocytes
11. Natural autoantibodies
12. Definition
13. Characteristics of natural autoantibodies
14. Target auto-Ags recognition by natural auto-Abs
15. Origin of natural autoantibodies
16. Selection of antibody repertoires (1)
17. Selection of antibody repertoires (2)
18. Negative selection of B lymphocytes
19. Positive selection - central
20. Positive selection - peripheral
21. Positive selection of B1 lymphocytes
22. Sources of autoantigens
23. Quantitative immunoblotting technique
24. Serum IgM reactivities against kidney antigens
25. Analysis of IgM reactivities with different self-Ags
26. IgM reactivities with different proteins
27. Repertoires analysis against stomach Ags (1)
28. IgG reactivity directed against P. aeruginosa Ags
29. Immunological homunculus (1)
30. Receptor editing (1)
31. Receptor editing (2)
32. B cell receptor editing
33. Natural vs. pathogenic autoantibodies
34. The majority of natural Abs are natural auto-Abs
35. Natural and autoimmune-associated auto-Abs
36. IgG autoantibody activity in normal mice
37. IgM autoantibody activity in normal mice
38. Normal IgG reactivities on a panel of self-Ags
39. Autoreactivity in health and disease
40. Repertoires analysis against stomach Ags (2)
41. Repertoires analysis against self-Ags
42. Self reactive IgG repertoires in healthy individuals
43. Myasthenia gravis - purified IgG vs. controls
44. Immunological homunculus (2)
45. Control of natural auto-Abs expression
46. Cryptic autoantibodies
47. IgG reactivities towards different protein extracts
48. IgG directed against stomach antigens
49. Self reactive IgG repertoires in healthy individuals
50. Factors controlling IgG reactivities in whole serum
51. Autologous anti-idiotypic Abs
52. IgG autoantibody activity is controlled by IgM
53. Inhibition of IgG reactivities
54. Antiphospholipid reactivities in heat-treated sera
55. Functions of natural autoantibodies (1)
56. Functions of natural autoantibodies (2)
57. Adaptive humoral immune response
58. Intravenous immunoglobulin (IVIg)
59. Reactivity profile of IVIg with liver antigens
60. Reported reactivities present in IVIg
61. Conclusion

Topics Covered

• Host defense mechanisms
• Innate immunity: first line of defense
• Physiological autoreactivity
• Autoimmunity
• Immunological tolerance
• Self-reactive B and T lymphocytes
• Natural autoantibodies
• Origins of natural autoantibodies
• Selection of antibody repertoires
• Sources of autoantigens
• Receptor editing
• Differences between natural and pathogenic autoantibodies
• Regulatory mechanisms that control the expression of natural autoantibodies
• Functions of natural autoantibodies
• Failure of control mechanisms is responsible for the occurrence of autoimmune diseases

Links

Series:

• Autoimmunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Luc Mouthon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.