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1. Introduction
2. What is autoimmunity?
3. Female dominance in most autoimmune diseases
4. Concept of tolerance
5. Central tolerance
6. Peripheral tolerance (1)
7. Peripheral tolerance (2)
8. Breakdown of tolerance
9. What is needed for autoimmunity to occur?
10. Autoimmune diseases (1)
11. Autoimmune diseases (2)
12. Susceptibility to autoimmune diseases
13. Infection and initiation of autoimmunity (1)
14. Initiation by bacterial infection
15. Infection and initiation of autoimmunity (2)
16. Initiation by viruses
17. Infection and initiation of autoimmunity (3)
18. Examples of important autoimmune diseases (1)
19. Temporal arteritis
20. Examples of important autoimmune diseases (2)
21. Systemic lupus erythematosus (SLE)
22. Risk of cardiovascular disease (CVD) in SLE
23. Nested case control design
24. Risk factors of CVD in SLE
25. Examples of important autoimmune diseases (3)
26. Atherosclerosis
27. Atherosclerosis is an inflammatory disease
28. Pro-inflammatory cytokines in atherosclerosis
29. Plaque rupture leads to thrombosis
30. The immune system in atherosclerosis (1)
31. Heat shoch proteins
32. Heat shock proteins (HSP) and atherosclerosis
33. The immune system in atherosclerosis (2)
34. Modification of LDL
35. PAF and PAF-like lipids
36. Oxidized LDL
37. The immune system in atherosclerosis (3)
38. Phosphorylcholine: epitope in OxLDL
39. ELSA study design
40. Study results
41. Immunological differences between sexes
42. Potential mechanisms for protective effects of aPC
43. The immune system in atherosclerosis (4)
44. Anti-phospholipid (aPL) antibodies
45. Annexin A5
46. Role of annexin-A5 in SLE-related CVDs (1)
47. Role of annexin-A5 in SLE-related CVDs (2)
48. Effect of IVIG on annexin A5 binding (1)
49. Effect of IVIG on annexin A5 binding (2)
50. Monoclonal aPL Ab inhibits annexin A5 binding
51. How can aPL antibodies cause disease?
52. Lupus anticoagulants
53. Summary and conclusions
54. Acknowledments

Topics Covered

• Autoimmunity
• High risk of atherosclerosis in autoimmune diseases, especially systemic lupus erythematosus (SLE)
• Antiphospholipid antibodies and atherosclerosis
• Association and risk factors for atherosclerosis and cardiovascular disease in SLE
• Autoimmune mechanisms in atherosclerosis in general

Links

Series:

• Autoimmunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Johan Frostegard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.