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Printable Handouts
Navigable Slide Index
- Introduction
- Malaria: one of the world's foremost killers
- Malaria
- Malaria endemic countries
- Children suffer the most from Malaria
- R. Ross and malaria transmission in mosquitos
- The sporogonic cycle
- Malaria in mosquito
- Schematic of malaria parasite sporogonic cycle
- The mosquito midgut
- Changes in the mosquito during feeding
- Mosquito midgut morphology
- Midgut morphology - digestive cells
- Anopheles midgut ultrastructure
- Microvilli and peritrophic matrix
- Water influx challenges the female mosquito
- Water removal from midgut
- The peritrophic matrix
- Peritrophic matrix composition
- Localization of Ae-Aper50 and Ag-Aper14
- AgAPN1 expression and recognition
- Digestive enzymes
- Spatial separation of enzymes
- Life and death in the mosquito (1)
- Anopheles midgut basal lamina
- Exflagellation (1)
- Exflagellation (2)
- Factors triggering exflagellation
- Ookinete
- Plasmodium berghei ookinetes
- In vitro invasion (1)
- In vitro invasion (2)
- Chitinase in ookinete
- Ookinete invading PM
- Ab's block plasmodium transmission to mosquito
- Ookinetes in the midgut
- CTRP KO - loss of infectivity to mosquito
- In vitro invasion
- The time bomb theory
- The time bomb theory of ookinete invasion (1)
- The time bomb theory of ookinete invasion (2)
- Oocyst
- Plasmodium berghei oocysts
- Ookinete to oocyst transformation
- Collagen IV expressed during oocyst growth
- Laminin in developing sporozoites
- Plasmodium and mosquito midgut basal lamina
- Insect immunity (1)
- Mosquito targets the parasite
- Insect immunity (2)
- Sporozoite
- Sporozoites in salivary glands
- A sporozoite based malaria vaccine
- Immunization experiments
- A sporozoite vaccine
- Reviewing aspects of malaria dynamics
- Life and death in the mosquito (2)
- Malaria-mosquito interaction affects dynamics
- Conclusion
Topics Covered
- Malaria: one of the world's foremost killers
- Malaria in the mosquito
- The mosquito midgut -- Exflagellation
- Ookinetes
- Antibodies block transmission to mosquito
- CTRP KO results in loss of infectivity to mosquito
- The time bomb theory of ookinete invasion
- Oocysts
- Interactions between Plasmodium and mosquito midgut
- Insect immunity
- Sporozoites
- A sporozoite based malaria vaccine
- Dynamics of Malaria in the mosquito
Talk Citation
Billingsley, P. (2011, May 29). Malaria in the mosquito [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 4, 2024, from https://doi.org/10.69645/PYRL4486.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Billingsley has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Microbiology
Transcript
Please wait while the transcript is being prepared...
0:00
My name
is Doctor Peter Billingsley.
I'm a Senior Director of
Quality Systems and Entomology
at a company called Sanaria
in Rockville, Maryland.
I'm going to talk to you
about Malaria in the mosquito.
0:15
Malaria is one of the
world's foremost killers.
Every year approximately
one million children
die of the disease, about
250 million people become ill
with malaria, and
at least $12 billion
are lost annually in
economic activity in terms
of gross domestic product due
just to malaria in Africa alone.
In addition, many thousands
of international travelers
fall ill to Malaria every year.
0:43
Of
The several malaria
parasites that infect humans,
Plasmodium falciparum
is responsible for more
deaths than any of the others.
Indeed, it is responsible for more
deaths in children in the world
than any other single
infectious agent.
Today alone, as you're listening
to this seminar, about 3
to 5 thousand children will die
of Malaria, about 1 to 3 million
in the coming in year.
1:08
This map shows the distribution
of Malaria across the world.
Malaria is found in areas where
conditions allow the parasite
to multiply within the vector,
where the temperature and humidity
conditions are suitable for
the persistence of mosquito
populations.
This means that the
parasite is restricted
to tropical and subtropical areas
at altitudes below 1500 meters.
Its distribution can, therefore,
be affected by climate changes,
especially global warming and
large population movements.
Plasmodium falciparum, which is the
major killing species of Malaria,
and Plasmodium malariae are
accounted in all these shaded areas
that you see here.
Plasmodium vivax
and Plasmodium ovale
are also common across
Sub-Saharan Africa.
Plasmodium ovale and many other
areas for Plasmodium vivax.
And more recently, a parasite
called Plasmodium knowlesi has begun
to emerge as a
zoonotic disease, that
is, a disease coming
animals in Malaysia.