Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Lecture structure
3. Bone structure
4. Cross talk between osteoblasts and osteoclasts
5. M-CSF cooperates with RANKL
6. EphrinB2 - EphB4 interaction
7. Immune system and bone: common regulators
8. Direct influence of the immune system on bone
9. IL17, IL1, IL6 and TNF are pro-osteoclastogenic
10. DKK1 and SOST inhibit osteoblast proliferation
11. Ig-like receptors induce osteoclastogenesis
12. PAMPs and TLRs modulate osteoclastogenesis
13. Osteoimmunoendocrinology
14. PPAR-gamma is a negative regulator
15. Effects of immune activation on bone structure
16. Arthritis disrupts bone structure and biomechanics
17. Anti TNF treatments stop bone erosions
18. Anti TNF treatments decrease osteoclastogenesis
19. Conclusions
20. Take-home messages

Topics Covered

• Osteoimmunology
• Bone structure
• Crosstalk between osteoblasts and osteoclasts
• Immunoregulation of bone
• Direct influence of the immune system on bone
• Osteoimmunoendocrinology
• Effects of immune activation on bone structure

Links

Series:

• Autoimmunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 21, 2010
• Archived on May 31, 2018

Financial Disclosures

• Prof. João Eurico Fonseca has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Ms. Joana Caetano-Lopes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.