Interleukin-17: from clone to clinic
24 min
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- Advances in the Understanding of Etiology (I)
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30 min
1. Infection and autoimmunity: a two-way relationship- Dr. Ricard Cervera
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35 min
2. Autoimmunity and atherosclerosis- Prof. Johan Frostegard
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47 min
3. Endothelium and autoimmunity- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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22 min
4. Prolactin has a pathogenic role in systemic lupus erythematosus- Prof. Luis Jara-Quezada
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44 min
5. Sjögren's syndrome: current knowledge and future prospects- Prof. Athanasios G. Tzioufas
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51 min
6. Genetic and environmental triggers of autoimmune thyroid diseases- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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38 min
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20 min
8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes- Dr. Luís Eduardo Coelho Andrade
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34 min
9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens- Dr. Luís Eduardo Coelho Andrade
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43 min
10. What causes primary biliary cholangitis?- Dr. M. Eric Gershwin
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30 min
11. Capillaroscopy in autoimmune rheumatic diseases- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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26 min
12. The past, present & future of ANA testing: history and challenges of ANA- Prof. Marvin J. Fritzler
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33 min
13. The past, present & future of ANA testing: changing bandwidth and future of ANA- Prof. Marvin J. Fritzler
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36 min
14. Diagnostic methods in autoimmunity- Mr. Steven Binder
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24 min
15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1- Prof. Chaim Putterman
- Dr. Noa Schwartz
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28 min
16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2- Prof. Chaim Putterman
- Dr. Noa Schwartz
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48 min
17. Novel aspects of systemic sclerosis- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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46 min
18. An update on the multiple faces of celiac disease- Prof. Aaron Lerner
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23 min
19. Protective autoantibodies- Prof. Elias Toubi
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32 min
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44 min
21. Rheumatic fever: a model of a post-infectious autoimmune disease- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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38 min
22. Intravenous immunoglobulins: clinical evidence- Prof. Shaye Kivity
- Latest Developments in the Field
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26 min
23. Adjuvants and autoimmunity- Dr. Eitan Israeli
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46 min
24. Antiphospholipid syndrome (APS): from pathogenesis to treatment- Prof. Roger Levy
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24 min
25. Vitamin D and autoimmunity- Dr. Shir Azrielant
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28 min
26. Pregnancy in rheumatic diseases- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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47 min
27. Pathogenic mechanisms of autoantibodies- Prof. Cees Kallenberg
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41 min
28. B lymphocytes on the frontline of autoimmunity- Prof. Pierre Youinou
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42 min
29. Apoptotic cell clearance deficiency- Prof. Martin Herrmann
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34 min
30. Auto-antibodies as predictors of autoimmune disease- Dr. Nicola Bizzaro
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46 min
31. Innate immunity and natural autoantibodies- Prof. Luc Mouthon
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45 min
32. Accelerated atherosclerosis in autoimmune rheumatic disease- Dr. Andrea Doria
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47 min
33. Pregnancy in autoimmune rheumatic diseases- Prof. Angela Tincani
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42 min
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39 min
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24 min
36. Immunologic mechanisms in systemic lupus erythematosus- Prof. Kok-Yong Fong
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23 min
37. Osteoimmunology- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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43 min
38. ANCA-associated systemic vasculitides- Prof. Loic Guillevin
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23 min
39. The common origin for diverse autoimmune diseases- Prof. Juan-Manuel Anaya
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76 min
40. Anti-cytokine therapy in rheumatoid arthritis- Prof. Piercarlo Sarzi-Puttini
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40 min
41. Sjogren's syndrome: autoimmune epithelitis- Prof. Haralampos Moutsopoulos
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31 min
42. Vitamin D and autoimmunity- Dr. Howard Amital
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25 min
43. Intravenous immunoglobulins: myth and reality- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- The history of systemic lupus erythematosus
- Early milestones in immunology
- Horror autotoxicus
- LE cells
- The complex immune system
- Anti-nuclear antibodies patterns
- ACR criteria for classification of SLE
- Pathogenic antibodies play significant roles in SLE
- Immunofluorescence staining
- Anti-DNA antibodies role in lupus nephritis
- Ro antibody and the fetal heart
- Suggested mechanism for fetal heart damage
- Pathogenesis of cutaneous lupus (1)
- Pathogenesis of cutaneous lupus (2)
- Apoptosis can initiate and maintain inflammation
- Immunologic impairments in SLE pathogenesis
- T cells play important roles in SLE
- Lupus and T cells
- Identification of Th17 cells
- Murine Th17 differentiation pathway
- Murine Th17 effects
- Regulatory T cells importance in SLE pathogenesis
- Human steady state
- Lupus disease state
- T regulatory cells in SLE
- Role of B cells in SLE pathogenesis
- B lymphocyte development
- Anti-B cell therapeutic options
- A perspective on B-cell-targeting therapy for SLE
- Anti CD20 in SLE: a review of off-label use study
- In summary
- Novel brain reactive antibodies in SLE
- Pathogenesis of neuropsychiatric lupus
- A summary of immunologic events in SLE
- Concluding remarks
- Thank you
Topics Covered
- Several immunologic mechanisms are involved in the pathogenesis of systemic lupus erythematosus
- The immune cells (T cells, B cells) are activated, and release various cytokines as well as autoantibodies
- Results in facilitation of the inflammatory process and organ damage
- The exact pathogenic mechanisms are still not fully known
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Talk Citation
Fong, K. (2010, July 22). Immunologic mechanisms in systemic lupus erythematosus [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/TPKB3693.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Kok-Yong Fong has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
