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1. Introduction
2. The history of systemic lupus erythematosus
3. Early milestones in immunology
4. Horror autotoxicus
5. LE cells
6. The complex immune system
7. Anti-nuclear antibodies patterns
8. ACR criteria for classification of SLE
9. Pathogenic antibodies play significant roles in SLE
10. Immunofluorescence staining
11. Anti-DNA antibodies role in lupus nephritis
12. Ro antibody and the fetal heart
13. Suggested mechanism for fetal heart damage
14. Pathogenesis of cutaneous lupus (1)
15. Pathogenesis of cutaneous lupus (2)
16. Apoptosis can initiate and maintain inflammation
17. Immunologic impairments in SLE pathogenesis
18. T cells play important roles in SLE
19. Lupus and T cells
20. Identification of Th17 cells
21. Murine Th17 differentiation pathway
22. Murine Th17 effects
23. Regulatory T cells importance in SLE pathogenesis
24. Human steady state
25. Lupus disease state
26. T regulatory cells in SLE
27. Role of B cells in SLE pathogenesis
28. B lymphocyte development
29. Anti-B cell therapeutic options
30. A perspective on B-cell-targeting therapy for SLE
31. Anti CD20 in SLE: a review of off-label use study
32. In summary
33. Novel brain reactive antibodies in SLE
34. Pathogenesis of neuropsychiatric lupus
35. A summary of immunologic events in SLE
36. Concluding remarks
37. Thank you

Topics Covered

• Several immunologic mechanisms are involved in the pathogenesis of systemic lupus erythematosus
• The immune cells (T cells, B cells) are activated, and release various cytokines as well as autoantibodies
• Results in facilitation of the inflammatory process and organ damage
• The exact pathogenic mechanisms are still not fully known

Links

Series:

• Autoimmunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Fong, K. (2010, July 22). Immunologic mechanisms in systemic lupus erythematosus [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/TPKB3693.
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Publication History

• Published on July 22, 2010
• Archived on May 31, 2018

Financial Disclosures

• Prof. Kok-Yong Fong has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.