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Navigable Slide Index
- Introduction
- "True" fungal pathogens
- Reproduction, ecology and infection
- Sex, ecology and infection in fungi
- Sex in fungal pathogens
- Fungi reproduce in a variety of ways
- Importance of sex and recombination
- How can we prove sex in fungal pathogens
- Assessing sexual vs. clonal reproduction (1)
- Assessing sexual vs. clonal reproduction (2)
- Complications: sexual populations can look clonal
- Complications: clonal populations can look sexual
- Step 1: develop multilocus genotype data set
- Step 2: phylogenetic analysis
- Step 3: look for linkage between loci
- Step 4: compare datasets
- Does sex happen in fungal pathogens?
- Histoplasma capsulatum (1)
- Histoplasma capsulatum (2)
- Coccidioides immitis (1)
- Coccidioides immitis (2)
- Pathogenic Cryptococcus
- Pathogenic species of Cryptococcus
- C. gattii molecular genotypes
- Molecular genotypes VGI and VGII
- Australian disease statistics
- VGII and the Vancouver Is. outbreak
- The Cryptococcus lifecycle
- The mating type locus
- Cryptococcus ecology and infection
- How Cryptococcus spores are formed?
- Questions and aims of study
- Analysis 1: Australian environmental populations
- Mating type bias in C. gattii
- Cluster analysis from 34 AFLP fragments
- Analysis of cluster 3 only
- PCA associates genotypes with trees
- The environmental Renmark population
- The Eucalyptus: a true host of Cryptococcus?
- Clinical vs. environmental populations of C. gatii
- Analysis 2: clinical populations - Australia/PNG
- Molecular type and mating type
- Phylogenetic and recombination analysis (IA)
- Recombination aligns with fertility
- Genetic differentiation among phylogroups
- MLSTs: two distinct VGII groups
- VG groups differ in fertility
- A quandry...
- VGI - why no sex?
- VGII - how sex?
- Sex and recombination between alpha cells only
- alpha-alpha mating and the Vancouver Is outbreak
- Refining population choice and recombination?
- Environmental populations revisited...
- Recombination in hollows with both mating types
- Recombination in hollow with a mating type only
- Pairings of Renmark isolates
- Does recombination happen on a global scale?
- Recombination on a global scale: MLST loci
- MLST data from Fraser et al., 2005
- Pairwise compatibility test for global VGI isolates
- Pairwise compatibility test for global VGII isolates
- C. gattii sex, ecology and infection: conclusions
- Finding sex and recombination - the final word
- Acknowledgements
Topics Covered
- The true fungal pathogens: reproduction at the interface of ecology and infection
- Sex in fungal pathogens: why do we want to know and how can we prove it?
- Molecular methods of assessing sexual versus clonal reproduction
- How does sex in fungal pathogens happen?
- Recombination in a sexual fungus: Histoplasma capsulatum
- Recombination in an "asexual" fungus: Coccidioides immitis
- Clonality and recombination in a sexual fungus: Cryptococcus
Talk Citation
Carter, D. (2010, July 22). The interface of ecology and infection in fungal pathogens: sex and recombination in Cryptococcus [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2018, from https://hstalks.com/bs/1675/.Talk Information
The interface of ecology and infection in fungal pathogens: sex and recombination in Cryptococcus
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