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1. Introduction
2. Synopsis of lecture
3. Phospholipids
4. Cardiolipin: introduction
5. Cardiolipin: structure
6. Cardiolipin: enzyme activation
7. Cardiolipin and aging
8. Cardiolipin: lipid and protein import
9. Cardiolipin as a regulator of apoptosis
10. Phosphatidylglycerol: introduction
11. Phosphatidylglycerol: a surfactant component
12. Phosphatidylglycerol: cardiolipin precursor
13. Phosphatidylethanolamine: introduction
14. Phosphatidylethanolamine: role in cell division
15. Phosphatidic acid: introduction
16. Phosphatidic acid: role in signal transduction
17. Phosphatidic acid in phospholipids synthesis
18. CDP-DG / Kennedy pathway
19. Phosphatidylethanolamine synthesis
20. Phosphatidic acid mitochondrial biosynthesis
21. Summary: mitochondrial phospholipid synthesis
22. Examples of using radiotracer incorporation
23. First example: cardiolipin biosynthesis
24. Phospholipid scramblase-3: introduction
25. Phospholipid scramblase-3: apoptosis
26. PLS3 mutants
27. Cardiolipin synthesis level in various cells
28. CLS activity levels in various cells
29. hCLS1 expression levels in various cells
30. Summary of PLS3 observations
31. Second example: phosphatidylethanolamine
32. P19 cells: introduction
33. GATA-4 expression
34. Electron micrograph of P19 cells at day 0
35. Electron micrograph of P19 cells at day 8
36. Phosphatidylethanolamine synthesis in P19 cells
37. Summary of P19 observations
38. Synopsis of part 2 of the lecture
39. Phospholipid acylgroups and phospholipases
40. Deacylation/reacylation pathway
41. Cardiolipin resynthesis: introduction
42. Use of radiotracer: cardiolipin resynthesis
43. Etomoxir - introduction
44. Cardiolipin synthesis - etomoxir
45. Example - regulation of cardiolipin resynthesis
46. Resynthesis in liver regeneration
47. MLCL AT expression in liver regeneration
48. Summary - liver regeneration studies
49. Challenges for the future

Topics Covered

• Mitochondrial phospholipids and their biosynthetic pathways: how to study mitochondrial phospholipid synthesis using radiotracer studies
• Examples of regulation of mitochondrial phospholipid biosynthesis
• Regulation of de novo cardiolipin biosynthesis by phospholipid scramblase-3
• Regulation of de novo phosphatidylethanolamine biosynthesis during cardiac cell differentiation
• Mitochondrial phospholipid remodeling
• Regulation of cardiolipin resynthesis in rat liver regeneration

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Hatch, G. (2018, June 1). Mitochondrial phospholipid synthesis and incorporation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/ZYWW3817.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Reviewed on June 1, 2018

Financial Disclosures

• Prof. Grant Hatch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.