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- Basic Concepts
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1. Molecular structure of the human genome
- Prof. Jonathan Wolfe
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2. Introduction to mutation and disease
- Prof. Jonathan Wolfe
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3. Introduction to genetic diseases
- Prof. Jonathan Wolfe
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4. Historical introduction to human diversity I
- Prof. Dallas Swallow
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5. Historical introduction to human diversity II
- Prof. Dallas Swallow
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6. Introduction to cytogenetics 1
- Dr. Sioban SenGupta
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7. Introduction to cytogenetics 2
- Dr. Sioban SenGupta
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8. Introduction to cytogenetics 3
- Dr. Sioban SenGupta
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9. The Y-chromosome
- Prof. Mark Jobling
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10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases
- Prof. Immo Scheffler
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11. Mechanisms of DNA repair by recombination
- Prof. James Haber
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12. Techniques utilized in molecular genetics
- Dr. Cecil Lewis
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13. Genome mapping
- Dr. Simon Gregory
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14. Copy number variation
- Dr. Ömer Gökçümen
- Genetics and Disease
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15. Genetic association studies
- Prof. David Balding
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16. Quantitative genetics and multifactorial inheritance
- Dr. Lara Bauman
- Human Evolutionary Genetics
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17. Population genetics
- Dr. Murray P. Cox
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18. Inference on human history through DNA
- Prof. Guido Barbujani
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19. Human adaptation
- Prof. Rasmus Nielsen
- Specialized Topics
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20. Accessing and using ENCODE data
- Prof. Peggy Farnham
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21. Pharmacogenetics
- Prof. Ann Daly
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22. Genetics in forensics
- Dr. Angel Carracedo
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23. The development and evolution of human gene therapy
- Prof. Theodore Friedmann
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24. Next generation sequencing technologies
- Dr. Krishna Veeramah
Printable Handouts
Navigable Slide Index
- Introduction
- Chromosomes of a human male: 46,XY
- The Y chromosome is dominantly sex-determining
- Ovary or testis?
- Specialized for sex
- The human sex chromosomes
- Evolution of the sex chromosomes
- Pseudoautosomal region 1 (PAR1)
- XY pairing in pachytene
- A gradient of recombination in PAR1
- Pseudoautosomal region 2
- Sex-chromosomal recombination
- Identifying the testis-determining factor
- Translocation XX males and XY females
- Principle of deletion mapping the TDF interval
- Sex-determining region Y (SRY)
- Evidence that SRY is TDF
- Randy the transgenic mouse
- The SRY gene and protein
- The sex-determining pathway downstream of SRY
- Turner syndrome
- Turner syndrome (45,X) phenotype
- Turner syndrome and X-linked genes
- Turner syndrome - candidate genes
- XY-homology
- Y-chromosomal aneuploidies
- A high mutation rate on the Y
- The weird genomic landscape of the Y
- Y-linked inheritance
- Other Y-associated phenotypes?
- Y-linked deafness (DFNY1)
- The human Y carries fertility factors
- Testis histologies in normal and infertile males
- Finding AZF candidate genes
- AZF phenotypes and candidate genes
- Genomic disorders
- NAHR in AZFa and AZFc infertility
- The 'hall of mirrors'
- Complex structural rearrangements
- Substrates for gene conversion
- Gene conversion is biased
- 'Genetic coherence' of the Y
- PAR1 shows no 'genetic coherence'
- A single ancestor for the Y
- Genome segments and effective population sizes
- Y haplogroup distribution
- Applications of Y diversity
- Thanks
Topics Covered
- Role in sex determination
- Recombination behaviour
- Sex-chromosomal aneuploidies
- Type and number of genes
- Rates and types of mutation
- Associated diseases
- Sequence organization
- Diversity of Y chromosome types in populations
Talk Citation
Jobling, M. (2009, December 28). The Y-chromosome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/QWSK9484.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Mark Jobling has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.