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- Evolutionary Perspectives
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1. Antibiotic resistance: a mechanistic overview
- Dr. Neil Woodford
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2. Mutation
- Prof. Stephen Gillespie
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3. Fitness in antibiotic resistant bacteria
- Prof. Stephen Gillespie
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4. Fitness and compensation
- Dr. Sébastian Gagneux
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5. Antibiotic resistance and the supragenome hypothesis
- Dr. Bambos Charalambous
- Epidemiology and Clinical Impact
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6. Methicillin resistant S. aureus and other resistances
- Prof. Mark Enright
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7. Risk factors for antibiotic resistance in Streptococcus pneumoniae
- Prof. Keith Klugman
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8. Beta-lactamases: clinical impact and epidemiology
- Prof. Sebastian Amyes
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9. Glycopeptide-resistant enterococci
- Dr. Neil Woodford
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10. Drug resistant tuberculosis: biology, epidemiology and control
- Dr. Christopher Dye
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11. Antiretroviral drug resistance
- Prof. Deenan Pillay
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12. Malaria - changing paradigms
- Dr. Janet Cox-Singh
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13. Advances in mode of action of antimalarials and resistance mechanisms 1
- Prof. David Warhurst
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14. Advances in mode of action of antimalarials and resistance mechanisms 2
- Prof. David Warhurst
- Diagnosis and Surveillance of Resistance
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15. Conventional and automated diagnostic methods
- Dr. Alan Johnson
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16. National and international surveillance of antibiotic resistance 1
- Prof. David Livermore
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17. National and international surveillance of antibiotic resistance 2
- Prof. David Livermore
- Controlling Antibiotic Resistance
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18. Controlling antibiotic resistance in the hospital environment
- Dr. Ian Eltringham
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19. Controlling antibiotic resistance in the community
- Dr. Peter Wilson
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20. Public policy to reduce antibiotic resistance
- Dr. Niels Frimodt-Møller
- The Antibiotic Resistance Future
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21. Overcoming resistance through novel drug targets
- Prof. Anthony Coates
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22. Medicinal chemistry strategies in combating antibiotic resistance
- Dr. Geoffrey Coxon
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23. Teixobactin kills pathogens without detectable resistance
- Prof. Kim Lewis
- Archived Lectures *These may not cover the latest advances in the field
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24. Molecular diagnosis of antibiotic resistance
- Dr. Tim McHugh
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25. Introduction to malaria
- Prof. David Warhurst
Printable Handouts
Navigable Slide Index
- Introduction
- Why monitor development of drug resistance?
- Diagnosis and monitoring: different disciplines
- Methods for determining resistance
- Molecular tools detect genotypic variation
- The tools to detect genotypic variation
- Considerations in adopting any diagnostic test
- Rapid techniques in clinical practice
- Streptococcus pneumoniae
- Penicillin resistance in S. pneumoniae
- Resistance diagnosis in S. pneumoniae
- S. pneumoniae: improve on culture
- S. pneumoniae: species specific PCR
- S. pneumoniae: MIC vs. RFLP pattern
- S. pneumoniae: MIC vs. RFLP pattern - results
- Mycobacterium tuberculosis
- Resistance diagnosis in M. Tuberculosis (1)
- Distribution of mutations in the RpoB gene
- M. tuberculosis resistance determination
- INNO-LiPA line probe assay
- London isoniazid resistant outbreak strains
- LiPA results for outbreak samples
- RifR samples from the north London outbreak
- Limitations
- Resistance diagnosis in M. Tuberculosis (2)
- Resistance diagnosis in M. Tuberculosis (3)
- Methicillin resistant Staphylococcus aureus
- Resistance diagnosis in MRSA (1)
- Resistance diagnosis in MRSA (2)
- BD GeneOhm MRSA assay
- Molecular target: MRSA DNA
- BD GeneOhmTM MRSA assay test procedure
- How is this screen being used?
- The culture step - do we need it?
- Developing technologies
- Molecular diagnosis of resistance
Topics Covered
- Diagnosis and monitoring are different disciplines
- Molecular tools detect genotypic variation
- Role for molecular tools in clinical practice
- Examples are penicillin binding proteins in Streptococcus pneumoniae, drug resistant Mycobacterium tuberculosis and MRSA
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
McHugh, T. (2009, December 31). Molecular diagnosis of antibiotic resistance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/1543/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Tim McHugh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.