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Printable Handouts
Navigable Slide Index
- Introduction
- Fitness and resistance
- Assessment of growth rate/fitness
- Growth formula
- Bacteria growth experience illustration
- Comparative method illustration
- Relative fitness of resistant M. tuberculosis
- Relative fitness and number of clinical isolates
- Relative fitness in medium vs. macrophages
- Other measures of fitness
- Fit the measure to the specie - Staphylococci
- Resistance not always results in fitness-deficit (1)
- Resistance not always results in fitness-deficit (2)
- Another method for testing fitness
- Genetic background influence on growth
- Sequential passage methodology
- Results of passage for 88 generation
- In vivo adaptation
- Spectra of compensated mutants isolated
- Adaptation occurs readily in humans
- Genetic basis for resistance and fitness
- Conclusion
Topics Covered
- Fitness and resistance
- Assessment of growth rate/fitness
- Sequential passage methodology
- In vivo adaptation
- Transmission of strains
- Bacteria rapidly adapt
Talk Citation
Gillespie, S. (2010, January 13). Fitness in antibiotic resistant bacteria [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/WFVD6845.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stephen Gillespie is in receipt of research grants from MMRC, EDCTP, Global Alliance for TB Drug Development. Professor Gillespie’s involvements in clinical trials are supported by active and placebo drug supplies from Bayer Schering Health Care and Sanofi Aventis, while also providing support with regulatory and drug safety advice. Neither company has a managerial role within the study, however. Professor Gillespie has also provided training to senior staff at Bayer Schering Health Care.