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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions
- Prof. Vanessa Sperandio
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19. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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20. The human indigenous microbiota
- Prof. David Relman
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22. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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23. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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24. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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25. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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26. Vaccines in the modern world
- Prof. Gordon Dougan
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27. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Topics
- The human microbiota - first work
- Cultivation of microbiota
- Benefits derived from our microbiota
- Why interest in human microbiome?
- "Community as pathogen"
- Indigenous microbiota - clinical problems
- Microbial community resilience and disease
- Phylogenetic surveys
- The tree of life
- Patterns of microbial diversity in the human body
- The tree of life - the bacterial domain
- The bacterial domain within the human colon
- Site-specific distributions of bacterial phyla
- Diversity of the human skin microbiome
- Skin microenvironments
- Ecological boundaries: features
- Rarefaction curves (1)
- Rarefaction curves (2)
- Number of species/strains seen in 3 individuals
- Human distal gut bacterial diversity
- Patterns of diversity within the human body
- Features of microbial diversity - mammals (1)
- Variability between and within subjects
- Diversity patterns among 12 obese individuals
- Diversity in the first year of life (1)
- Diversity in the first year of life (2)
- Early days: evidence of opportunistic exposures
- Later days: emergence of individuality
- Features of microbial diversity - mammals (2)
- Functional capacity in the human gut
- Families have more functionally similar microbiome
- Early metagenomic analysis of gut microbiome
- Methanogenesis and disease
- Model of oral anaerobic community interactions
- Challenges and future directions
- Challenges
- Viruses outnumber bacteria
- The "long tail"
- The rare and uncultivated
- Single cell genomics
- Conclusions
- Acknowledgements
Topics Covered
- Benefits derived from our microbiota
- Clinical problems associated with the indigenous microbiota
- Degradation of fitness landscape
- Phylogenetic surveys
- Patterns of microbial diversity in the human body
- Site-specific distributions of bacterial phyla in healthy humans
- Skin microenvironments
- Ecological boundaries
- Rarefaction curves
- What are the factors that regulate or restrict human indigenous microbial diversity?
- What are the features of early microbial colonization in the human body?
- Early days: evidence of opportunistic exposures
- Later days: emergence of individuality
- Features of indigenous microbial diversity in mammals
- Families have more functionally similar microbiomes
- Challenges and future directions
Links
Series:
Categories:
Talk Citation
Relman, D. (2010, August 11). The human indigenous microbiota [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/AJWQ2834.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Relman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.