• Principles in Bacterial Pathogenesis
• 43 min
  1. The molecular basis of bacterial pathogenicity: an overview

  • Prof. B. Brett Finlay
• Gram Negative Pathogens
• 50 min
  2. Deciphering shigella invasion of epithelial cells

  • Prof. Philippe Sansonetti
• 43 min
  3. Legionella pneumophila: an intracellular pathogen of phagocytes

  • Dr. Craig Roy
• 57 min
  4. Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease

  • Prof. John Mekalanos
• 34 min
  5. Bordetella pertussis

  • Prof. Alison Weiss
• 37 min
  6. Salmonellae: molecular basis of infection

  • Prof. Samuel Miller
• 43 min
  7. The diversity of Escherichia coli infections

  • Prof. Michael Donnenberg
• 18 min
  8. Bacterial activation of epithelial signaling

  • Prof. Alice Prince
• 48 min
  9. Human pathogenic Yersinia species

  • Prof. James Bliska
• 32 min
  10. From CagA to CagA: the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A

  • Dr. Antonello Covacci
• 46 min
  11. Dental pathogens

  • Prof. Ann Progulske-Fox
• 35 min
  12. Haemophilus

  • Prof. Robert Munson
• Gram Positive Pathogens
• 53 min
  13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model

  • Prof. Pascale Cossart
• 42 min
  14. The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition

  • Prof. William Jacobs
• 48 min
  15. Molecular pathogenesis and prevention of Staphylococcus aureus infections

  • Prof. Olaf Schneewind
• 49 min
  16. Streptococcus pyogenes disease and molecular pathogenesis

  • Prof. P. Patrick Cleary
• Host Responses
• 29 min
  17. Microbial recognition and the immune response

  • Dr. Dana Philpott
• 40 min
  18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions

  • Prof. Vanessa Sperandio
• 47 min
  19. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 56 min
  20. The human indigenous microbiota

  • Prof. David Relman
• 53 min
  21. Human genetics of infectious diseases: the example of bacterial/mycobacterial infections

  • Dr. Laurent Abel
• 47 min
  22. Role of neutrophils in acute lung injury and repair

  • Prof. Gregory Downey
• Preventatives and Therapeutics
• 35 min
  23. Antibiotics and antibiotic resistance

  • Prof. Gerry Wright
• 36 min
  24. Vaccines: a health insurance of the 21st century

  • Prof. Rino Rappuoli
• 41 min
  25. Biodefense vaccines

  • Prof. James Nataro
• Archived Lectures *These may not cover the latest advances in the field
• 39 min
  26. Vaccines in the modern world

  • Prof. Gordon Dougan
• 39 min
  27. Bacterial infection of epithelial signaling

  • Prof. Alice Prince

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Topics
3. The human microbiota - first work
4. Cultivation of microbiota
5. Benefits derived from our microbiota
6. Why interest in human microbiome?
7. "Community as pathogen"
8. Indigenous microbiota - clinical problems
9. Microbial community resilience and disease
10. Phylogenetic surveys
11. The tree of life
12. Patterns of microbial diversity in the human body
13. The tree of life - the bacterial domain
14. The bacterial domain within the human colon
15. Site-specific distributions of bacterial phyla
16. Diversity of the human skin microbiome
17. Skin microenvironments
18. Ecological boundaries: features
19. Rarefaction curves (1)
20. Rarefaction curves (2)
21. Number of species/strains seen in 3 individuals
22. Human distal gut bacterial diversity
23. Patterns of diversity within the human body
24. Features of microbial diversity - mammals (1)
25. Variability between and within subjects
26. Diversity patterns among 12 obese individuals
27. Diversity in the first year of life (1)
28. Diversity in the first year of life (2)
29. Early days: evidence of opportunistic exposures
30. Later days: emergence of individuality
31. Features of microbial diversity - mammals (2)
32. Functional capacity in the human gut
33. Families have more functionally similar microbiome
34. Early metagenomic analysis of gut microbiome
35. Methanogenesis and disease
36. Model of oral anaerobic community interactions
37. Challenges and future directions
38. Challenges
39. Viruses outnumber bacteria
40. The "long tail"
41. The rare and uncultivated
42. Single cell genomics
43. Conclusions
44. Acknowledgements

Topics Covered

• Benefits derived from our microbiota
• Clinical problems associated with the indigenous microbiota
• Degradation of fitness landscape
• Phylogenetic surveys
• Patterns of microbial diversity in the human body
• Site-specific distributions of bacterial phyla in healthy humans
• Skin microenvironments
• Ecological boundaries
• Rarefaction curves
• What are the factors that regulate or restrict human indigenous microbial diversity?
• What are the features of early microbial colonization in the human body?
• Early days: evidence of opportunistic exposures
• Later days: emergence of individuality
• Features of indigenous microbial diversity in mammals
• Families have more functionally similar microbiomes
• Challenges and future directions

Links

Series:

• Microbiota
• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Talk Citation

Publication History

• Published on October 29, 2009
• Updated on August 11, 2010

Financial Disclosures

• Prof. David Relman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.