• Principles in Bacterial Pathogenesis
• 43 min
  1. The molecular basis of bacterial pathogenicity: an overview

  • Prof. B. Brett Finlay
• Gram Negative Pathogens
• 50 min
  2. Deciphering shigella invasion of epithelial cells

  • Prof. Philippe Sansonetti
• 43 min
  3. Legionella pneumophila: an intracellular pathogen of phagocytes

  • Dr. Craig Roy
• 57 min
  4. Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease

  • Prof. John Mekalanos
• 34 min
  5. Bordetella pertussis

  • Prof. Alison Weiss
• 37 min
  6. Salmonellae: molecular basis of infection

  • Prof. Samuel Miller
• 43 min
  7. The diversity of Escherichia coli infections

  • Prof. Michael Donnenberg
• 18 min
  8. Bacterial activation of epithelial signaling

  • Prof. Alice Prince
• 48 min
  9. Human pathogenic Yersinia species

  • Prof. James Bliska
• 32 min
  10. From CagA to CagA: the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A

  • Dr. Antonello Covacci
• 46 min
  11. Dental pathogens

  • Prof. Ann Progulske-Fox
• 35 min
  12. Haemophilus

  • Prof. Robert Munson
• Gram Positive Pathogens
• 53 min
  13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model

  • Prof. Pascale Cossart
• 42 min
  14. The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition

  • Prof. William Jacobs
• 48 min
  15. Molecular pathogenesis and prevention of Staphylococcus aureus infections

  • Prof. Olaf Schneewind
• 49 min
  16. Streptococcus pyogenes disease and molecular pathogenesis

  • Prof. P. Patrick Cleary
• Host Responses
• 29 min
  17. Microbial recognition and the immune response

  • Dr. Dana Philpott
• 40 min
  18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions

  • Prof. Vanessa Sperandio
• 47 min
  19. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 56 min
  20. The human indigenous microbiota

  • Prof. David Relman
• 53 min
  21. Human genetics of infectious diseases: the example of bacterial/mycobacterial infections

  • Dr. Laurent Abel
• 47 min
  22. Role of neutrophils in acute lung injury and repair

  • Prof. Gregory Downey
• Preventatives and Therapeutics
• 35 min
  23. Antibiotics and antibiotic resistance

  • Prof. Gerry Wright
• 36 min
  24. Vaccines: a health insurance of the 21st century

  • Prof. Rino Rappuoli
• 41 min
  25. Biodefense vaccines

  • Prof. James Nataro
• Archived Lectures *These may not cover the latest advances in the field
• 39 min
  26. Vaccines in the modern world

  • Prof. Gordon Dougan
• 39 min
  27. Bacterial infection of epithelial signaling

  • Prof. Alice Prince

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Scientific classification of the genus Yersinia
3. Common features
4. Classification of strains
5. Level of pathogenicity
6. Overview of Yersinia infections
7. Intestinal Yersinia infections
8. Intestinal Yersinia infections: transmission
9. Intestinal infections: outcomes (1)
10. Intestinal infections: outcomes (2)
11. Plague: overview
12. Transmission modes of Y. pestis
13. Unique features of Y. pestis (1)
14. Unique features of Y. pestis (2)
15. Plague: bubonic
16. Plague: pneumonic (1)
17. Plague: pneumonic (2)
18. Attributes of a successful bacterial pathogen
19. Adhesion and invasion determinants
20. Mechanism of Yersinia invasion
21. Invasin
22. Mechanism of invasin-promoted uptake
23. Systemic infection may bypass lymph colonization
24. Regulate gene expression
25. Avoid, subvert or co-opt host immune responses
26. Localization of Y. pseudotuberculosis in cells
27. Extracellular location of Y. enterocolitica
28. Simplified Yersinia pathogenesis model
29. Summary of vacuole trafficking studies
30. Model of "YCV" trafficking
31. Simplified Yersinia pathogenesis model
32. pCD1 encodes type III protein secretion system
33. Yersinia type III secretion system
34. Overview of Yop effectors
35. Inhibition of signaling pathways by Yops
36. The type III "injectisome"
37. LcrV
38. Acquire nutrients to replicate
39. Genes involved in uptake of iron
40. Some open questions in Yersinia pathogenesis
41. Acknowledgements
42. References

Topics Covered

• Classification of strains
• Different degrees of pathogenicity
• Intestinal Yersinia infections: transmission and outcomes
• Transmission modes of Y. pestis
• Pneumonic and bubonic plague
• Adhesion and invasion
• Invasin
• Gene expression
• Vacuole trafficking
• Secretion systems

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 29, 2009

Financial Disclosures

• Prof. James Bliska has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.