On Sunday, April 20th 2025, starting 8:30am GMT, there will be maintenance work that will involve the website being unavailable during parts of the day. We apologize for any inconvenience this may cause and appreciate your understanding.
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Principles in Bacterial Pathogenesis
-
43 min
1. The molecular basis of bacterial pathogenicity: an overview- Prof. B. Brett Finlay
- Gram Negative Pathogens
-
50 min
2. Deciphering shigella invasion of epithelial cells- Prof. Philippe Sansonetti
-
43 min
-
57 min
-
34 min
5. Bordetella pertussis- Prof. Alison Weiss
-
37 min
6. Salmonellae: molecular basis of infection- Prof. Samuel Miller
-
43 min
7. The diversity of Escherichia coli infections- Prof. Michael Donnenberg
-
18 min
8. Bacterial activation of epithelial signaling- Prof. Alice Prince
-
48 min
9. Human pathogenic Yersinia species- Prof. James Bliska
-
32 min
-
46 min
11. Dental pathogens- Prof. Ann Progulske-Fox
-
35 min
12. Haemophilus- Prof. Robert Munson
- Gram Positive Pathogens
-
53 min
13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model- Prof. Pascale Cossart
-
42 min
-
48 min
15. Molecular pathogenesis and prevention of Staphylococcus aureus infections- Prof. Olaf Schneewind
-
49 min
16. Streptococcus pyogenes disease and molecular pathogenesis- Prof. P. Patrick Cleary
- Host Responses
-
29 min
17. Microbial recognition and the immune response- Dr. Dana Philpott
-
40 min
18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions- Prof. Vanessa Sperandio
-
47 min
19. Toll-like receptor signalling during infection and inflammation- Prof. Luke O'Neill
-
56 min
20. The human indigenous microbiota- Prof. David Relman
-
53 min
-
47 min
22. Role of neutrophils in acute lung injury and repair- Prof. Gregory Downey
- Preventatives and Therapeutics
-
35 min
23. Antibiotics and antibiotic resistance- Prof. Gerry Wright
-
36 min
24. Vaccines: a health insurance of the 21st century- Prof. Rino Rappuoli
-
41 min
25. Biodefense vaccines- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
-
39 min
26. Vaccines in the modern world- Prof. Gordon Dougan
-
39 min
27. Bacterial infection of epithelial signaling- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Bordetella pertussis
- Whooping cough (or pertussis)
- Whooping cough case presentation
- Pertussis: a medical success story, with its limits
- Pertussis in the US, 1980-2008
- Pertussis is a cyclic
- Pertussis vaccine
- Vaccine efficacy following household exposure
- Pertussis vaccine promotes little herd immunity
- Pertussis vs. Influenza vaccine
- Immunization does not yield life-long immunity
- Pertussis by age group
- The molecular aspect of whooping cough
- Classical whooping cough
- Chronic coughing disease
- Pertussis is two diseases
- B. pertussis is a strict human pathogen
- Infection causes suboptimal immune responses
- Virulence factors of B. pertussis - toxins
- Pertussis toxin
- Adenylate cyclase toxin (ACT)
- ACT inhibits neutrophil phagocytosis
- Dermonecrotic toxin
- Tracheal cytotoxin
- Virulence factors of B. pertussis - adhesins
- Adhesins of B. pertussis
- Adhesins - not just sticky proteins
- Composition of acellular pertussis vaccine
- Vaccine induced antibody-mediated immunity
- Anti-toxin antibodies
- Anti-adherence antibodies
- Bactericidal antibodies
- Opsono-phagocytosis
- Phagocytosis assay
- Neutrophil phagocytosis
- Neutralizing Ab to ACT promote phagocytosis
- Opsono-phagocytosis activity after vaccination
- Vaccine does not enhance phagocytosis
- Opsono-phagocytosis activity after infection
- Phagocytosis with convalescent serum
- ACT blocks phagocytosis in WT
- Phagocytosis with serum depleted for Ab to FHA
- FHA is both bound to the bacteria and secreted
- Ab to FHA delivers ACT to neutrophils
- Role of Complement in immunity to B. pertussis
- Complement killing assay
- Complement cascade
- Complement killing activity after vaccination
- Complement activity after vaccination
- Complement killing activity after infection
- Blocking response decays with time
- IgA involvement in blocking activity
- Antibody dependent complement killing
- Summary
- Acknowledgements
- Thank you
Topics Covered
- Pertussis: a medical success story and the limits of medical success
- Pertussis is the only vaccine-preventable disease that is increasing in incidence in the USA
- Pertussis is cyclic
- Pertussis vaccine and its efficacy
- Vaccine prevents disease not carriage
- Immunization does not yield life-long immunity
- Human to human transmission by respiratory droplets
- Classical whooping cough and chronic coughing disease
- Pertussis is two diseases
- B. pertussis is a strict human pathogen
- Virulence factors of Bordetella pertussis
- Pertussis toxin
- Adhesins
- Composition of acellular pertussis vaccine
- Anti-toxin, anti-adherence and bactericidal antibodies
- Opsono-phagocytosis
- Role of complement in immunity to B. pertussis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Weiss, A. (2009, October 29). Bordetella pertussis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/ODNY7477.Export Citation (RIS)
Publication History
- Published on October 29, 2009
Financial Disclosures
- Prof. Alison Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
