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1. Introduction
2. Bordetella pertussis
3. Whooping cough (or pertussis)
4. Whooping cough case presentation
5. Pertussis: a medical success story, with its limits
6. Pertussis in the US, 1980-2008
7. Pertussis is a cyclic
8. Pertussis vaccine
9. Vaccine efficacy following household exposure
10. Pertussis vaccine promotes little herd immunity
11. Pertussis vs. Influenza vaccine
12. Immunization does not yield life-long immunity
13. Pertussis by age group
14. The molecular aspect of whooping cough
15. Classical whooping cough
16. Chronic coughing disease
17. Pertussis is two diseases
18. B. pertussis is a strict human pathogen
19. Infection causes suboptimal immune responses
20. Virulence factors of B. pertussis - toxins
21. Pertussis toxin
22. Adenylate cyclase toxin (ACT)
23. ACT inhibits neutrophil phagocytosis
24. Dermonecrotic toxin
25. Tracheal cytotoxin
26. Virulence factors of B. pertussis - adhesins
27. Adhesins of B. pertussis
28. Adhesins - not just sticky proteins
29. Composition of acellular pertussis vaccine
30. Vaccine induced antibody-mediated immunity
31. Anti-toxin antibodies
32. Anti-adherence antibodies
33. Bactericidal antibodies
34. Opsono-phagocytosis
35. Phagocytosis assay
36. Neutrophil phagocytosis
37. Neutralizing Ab to ACT promote phagocytosis
38. Opsono-phagocytosis activity after vaccination
39. Vaccine does not enhance phagocytosis
40. Opsono-phagocytosis activity after infection
41. Phagocytosis with convalescent serum
42. ACT blocks phagocytosis in WT
43. Phagocytosis with serum depleted for Ab to FHA
44. FHA is both bound to the bacteria and secreted
45. Ab to FHA delivers ACT to neutrophils
46. Role of Complement in immunity to B. pertussis
47. Complement killing assay
48. Complement cascade
49. Complement killing activity after vaccination
50. Complement activity after vaccination
51. Complement killing activity after infection
52. Blocking response decays with time
53. IgA involvement in blocking activity
54. Antibody dependent complement killing
55. Summary
56. Acknowledgements
57. Thank you

Topics Covered

• Pertussis: a medical success story and the limits of medical success
• Pertussis is the only vaccine-preventable disease that is increasing in incidence in the USA
• Pertussis is cyclic
• Pertussis vaccine and its efficacy
• Vaccine prevents disease not carriage
• Immunization does not yield life-long immunity
• Human to human transmission by respiratory droplets
• Classical whooping cough and chronic coughing disease
• Pertussis is two diseases
• B. pertussis is a strict human pathogen
• Virulence factors of Bordetella pertussis
• Pertussis toxin
• Adhesins
• Composition of acellular pertussis vaccine
• Anti-toxin, anti-adherence and bactericidal antibodies
• Opsono-phagocytosis
• Role of complement in immunity to B. pertussis

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 29, 2009

Financial Disclosures

• Prof. Alison Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.