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Printable Handouts
Navigable Slide Index
- Introduction
- Shigella invasion process
- Histopathology of shigellosis
- Functional genomics of S. flexneri
- The shigellosis disease process
- Two mechanisms for bacterial penetration
- pWR100: the virulence plasmid of S. flexneri 5a
- The Shigella invasion pathogenicity island
- Assembly of type III protein delivery system
- IpaB and IpaD: sensor-adaptor at the needle tip
- Shigella trigger mechanism for cell invasion
- Signaling in the penetration process
- Cortactin - second wave of signaling
- IpaC induces Src autophosphorylation
- Src is activated early at Shigella entry site
- Src is necessary for actin foci formation
- Cortactin silencing blocks the entry process
- C351 insertion in IpaC effector C-terminal domain
- IpaC last 72 aa induce actin-foci-like structures
- IpaC-dependent actin nucleation
- Shigella motility within and between the cells
- Actin-dependent intracellular motility of Shigella
- Shigella intracellular motility - video
- Entry and cell-to cell spread of Shigella
- Acknowledgements
Topics Covered
- A genetic and molecular analysis of the mechanisms used by the bacterial pathogen Shigella to invade epithelial cells
- Identification of bacterial effectors of invasion, mode of delivery, nature of cell targets
- How a bacterial pathogen like Shigella causes the rupture and inflammatory destruction of the intestinal epithelial barrier
- How it also regulates the inflammatory response
- The accent is on identification of the bacterial effectors and their cellular targets
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Talk Citation
Sansonetti, P. (2009, October 29). Deciphering shigella invasion of epithelial cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/WYOV3904.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Philippe Sansonetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.