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Printable Handouts
Navigable Slide Index
- Introduction
- Why do we have NK cells?
- NK cells are important in viral immunity
- NK cells participation during a viral infection
- NK cell responses to interferons and cytokines
- NK cells are activated as bystanders
- NK cells control replication of MCMV
- NK MCMV control - in certain genetic backgrounds
- NK resistance segregates as a single locus
- MCMV resistance maps to the "NK complex"
- Ly49 receptors - background
- Inhibitory and activating Ly49 receptors
- MCMV genome
- Ly49H ligand = MCMV m157
- Direct recognition: NK recognition of viral ligands
- Ly49H is the receptor for m157 glycoprotein
- m157 binds Ly49H+ NK - not Ly49H- NK
- MCMV results in m157 loss-of-function
- Why did m157 evolve and why is it maintained?
- Ly49 genes are polymorphic
- Ly49H-relatives
- m157 binds to NK cells in 129/J mice
- m157 binds to inhibitory Ly49I(129) in 129/J mice
- m157 structure
- Virus-driven NK receptor evolution?
- NK response to MCMV - direct and indirect
- Do other Ly49 receptors protect against MCMV?
- Ly49 genes in different mouse strains
- MA/My mice are MCMV-resistant
- MA/My resistant requires 2 genes
- NK recognition of host-encoded ligands
- NKG2D receptor and DAP11
- NKG2D ligands
- CMV effectively neutralize NKG2D recognition
- MCMV blocks expression of NKG2D ligands
- NK cells and cytomegalovirus
- NK cells and poxviruses
- NK cells are required during early infection
- Mousepox infection induces NKG2D ligands
- Blocking NKG2D renders B6 mice susceptible
- Blocking NKG2D on NK increase viral titers
- NK cell depletion impairs T cell responses
- NK cells and mousepox - summary
- Natural cytotoxicity receptors
- NKp46 deficient mice are more susceptible to flu
- NK cells in human viral immunity
- NK complex in mouse and human
- KIR genes have replaced Ly49 in humans
- Association of KIR genes with viral infection
- NK cells implicated in other viral infections
- Acknowledgements
- References
Topics Covered
- Why do we have NK cells?
- Importance in viral immunity
- NK cell responses to interferon alpha/beta and cytokines induced by virus
- Control of replication in viruses
- Mouse cytomegalovirus (MCMV)
- Ly49 receptors
- Inhibitory and activating Ly49 receptors
- Direct recognition of virus-infected cells by NK cells
- Ly49H is the receptor for m157 MCMV glycoprotein
- Why did m157 evolve and why is it maintained?
- Ly49 genes are polymorphic
- Virus-driven NK receptor evolution
- Is Ly49H an exception or do other activating Ly49 receptors protect against MCMV?
- Direct recognition of virus-infected cells by NK cells
- NK cells and cytomegalovirus
- NK cells and poxviruses
- Natural cytotoxicity receptors
- NK cells in human viral immunity
- Association of KIR genes with viral infection
Links
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Talk Citation
Lanier, L. (2009, September 23). NK cells in viral immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/RWPR1491.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.