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1. Introduction
2. NK cell functions
3. NK cell recognition
4. MHC deficient cells are susceptible to NK attack
5. NK cells destroy cells lacking MHC molecules
6. MHC-specific inhibitory receptors
7. Basis of missing self recognition
8. The "at least one" model of NK cell self tolerance
9. An alternative view of NK cell self tolerance
10. MHC-I deficient NK impaired in tumor cell killing
11. MHC-I deficient NK impaired in functional assays
12. NK tolerance in MHC deficient and normal animals
13. Receptors for self MHC in H-2b mice
14. NK cells lacking H-2b-specific inhibitory receptors
15. NK lacking MHC receptors are self tolerant
16. NK lacking MHC receptors are hyporesponsive
17. Evidence from the absence of target cells
18. Nature of hyporesponsive NK cells
19. Hyporesponsive NK cells are mature cells
20. Subsets of NK cells based on specificity
21. Different routes to self-tolerance
22. How is hyporesponsiveness imposed?
23. Two models for induction of NK cell self tolerance
24. Predictions of a mixed chimera
25. Fetal liver chimeras to test models of tolerance
26. MHC-I+/MHC-I-/- mixed fetal liver chimeras
27. Chimeric mice fail to reject class I-deficient cells
28. Data to date support disarming model
29. Different receptors specific for self MHC
30. Binary state or rheostat?
31. Responsiveness of C+/I+ NK cells
32. Intrinsic responsiveness of NK cells
33. Receptor co-expression enhances responsiveness
34. Granule exocytosis and number of self receptors
35. Tuning NK cell responsiveness
36. Conclusions
37. Acknowledgements

Topics Covered

• NK cell "education"
• NK cells in normal animals attack cells that lack some or all self MHC class I molecules
• NK cells that lack inhibitory receptors for self MHC class I are rendered hyporesponsive and self tolerant
• Hyporesponsiveness of NK cells is induced by target cells lacking MHC I, as in a mixed chimera
• Responsiveness of NK cells varies depending on how many MHC I-specific receptors they express
• NK cell education ensures that NK cells are optimally responsive yet not autoreactive

Links

Series:

• Natural Killer Cell Biology

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on September 23, 2009

Financial Disclosures

• Prof. David Raulet has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.