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See webinar details- How Natural Killer Cells Recognize Self
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53 min
1. Education and tuning of natural killer cells- Prof. Eric Vivier
- Dr. Sophie Ugolini
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46 min
2. Disarming of autoreactive NK cells- Prof. David Raulet
- Development and Function of Natural Killer Cell Subsets
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23 min
3. Natural killer cell development- Dr. Francesco Colucci
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48 min
4. Natural killer cells: development, diversity and applications to human disease- Prof. Mike Caligiuri
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41 min
5. NK cells in viral immunity- Prof. Lewis Lanier
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58 min
6. NK cell subsets and interactions with dendritic cells- Prof. Christian Münz
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53 min
7. Immunodeficiencies and genetic mutations affecting NK cells in humans- Dr. Jordan Orange
- Natural Killer Cell Receptors and Signaling
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42 min
8. Evolution of NK cell receptors- Prof. John Trowsdale
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26 min
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37 min
10. Mechanisms of natural killer cell cytotoxicity- Prof. Carsten Watzl
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55 min
11. NK cell signaling to cytotoxicity - part I- Prof. Dan Billadeau
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39 min
12. NK cell signaling to cytotoxicity - parts II & III- Prof. Dan Billadeau
- Archived Lectures *These may not cover the latest advances in the field
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38 min
13. NK cells in viral immunity- Prof. Lewis Lanier
Printable Handouts
Navigable Slide Index
- Introduction
- NK cell recognition strategies
- Innate immunity: the natural killer cell model
- The immune system
- Functions of NK cells
- NK cells relationships with other immune cells
- NK cell killing
- NK cell recognition
- Cartoon of NK cell activity
- Molecules involved in NK-target cell recognition
- Mouse and human NK cell - target cell synapse
- NK recognition strategies
- ITIM-bearing receptors
- The KIR family
- Inhibitory NKR
- The family of ITIM-containing-molecules
- ITIM-mediated inhibition of NK cell activation (1)
- ITIM-mediated inhibition of NK cell activation (2)
- ITIM-mediated inhibition of NK cell activation (3)
- Model for inhibitory receptor signaling by KIR (1)
- Model for inhibitory receptor signaling by KIR (2)
- Two components of inhibitory signaling by ITIM
- NK cell education via MHC class I recognition
- Natural killer cell definition
- Cr(51) release assay
- NK activation and degranulation assay
- Gated on NK cells
- What are the naturally-occurring killer cells?
- KIR-NKG2A- NK cells are hyporesponsive
- KIR-NKG2A- NK cells in the mouse
- KIR-NKG2A- NK cell phenotype
- NK cells recognition of MHC-I in different settings
- Role of self recognition in NK cell education
- 2 inhibitory KIR survey > 160 HLA-C molecules
- NK cells subsets
- NK cells w/ inhibitory receptors for self HLA-I
- Dual function of MHC class I recognition
- How "natural" are natural killer cells?
- MHC-I recognition by both KIR and TCR
- Clinical manipulation of MHC-I recognition by NK
- Cellular immunotherapy
- Results of haplo-identical transplantation
- Blocking NK cell inhibition by monoclonal Ab
- New NK cells roles
- Acknowledgment
Topics Covered
- Innate immunity
- Natural killer cells
- NK cell recognition strategies
- ITIM-bearing receptors
- NK cell education via MHC class I recognition
- Clinical manipulation of MHC class I recognition by NK cells
Links
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Talk Citation
Vivier, E. and Ugolini, S. (2009, September 23). Education and tuning of natural killer cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/1450/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Eric Vivier has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Sophie Ugolini has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Education and tuning of natural killer cells
Published on September 23, 2009
53 min
