• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. Innate-like cells and protection of the young animal
4. Waves of gamma-delta cell development
5. Testing immunological mechanisms
6. Th1 protection by alpha-beta T cells
7. T-cells in young mice
8. Gamma-delta cells confer young mice resistance
9. Working model for gamma-delta cells
10. Studying the situation in human neonates
11. Cytokines production by different T-cells
12. Precocious activation of gamma-delta T cells
13. Section 3: interim conclusions
14. Toll like receptors and their ligands
15. Gamma-delta cells in pre-term neonates (1)
16. Gamma-delta cells in pre-term neonates (2)
17. Summary of section 3
18. Ligands for innate-like / unconventional T cells
19. Ligands and "unconventional MHC" - iNKT
20. Ligands and "unconventional MHC" - MAIT cells
21. Ligands and "unconventional MHC" - gamma-delta
22. Unconventional T cell "ligands"
23. "New Tac" FVB mice
24. Characterization of the mutant strain
25. The Taconic defect is in the stromal compartment
26. Skint1 structure and possible topology
27. The efficacy of Skint-1
28. What is Skint-1?
29. Skint-1 expressed in the thymus and skin
30. Summary of gamma-delta cell selection
31. Is Skint-1 a positively selecting agonist?
32. Molecules that regulate unconventional T cells
33. Recognition by human gamma-delta T cells
34. Peripheral gamma-delta cell response to infection
35. Non-peptide activators produced by parasites
36. Sources of activators for human gamma-delta cells
37. Clinical trial: Francesco Dieli - Palermo
38. Cell subset dynamics in response to treatment
39. Gamma-delta responses in a cancer patient
40. Data so far... clinical outcome
41. Human peripheral blood Vgamma9Vdelta2+ cells

Topics Covered

• Innate-like cells and protection of the young animal
• Waves of gamma-delta cell development
• Th1 protection by alpha-beta T cells
• Gamma-delta cells confer young mice resistance
• Studying the situation in human neonates
• Cytokines production by different T-cells
• Toll like receptors and their ligands
• Gamma-delta cells in pre-term neonates
• Ligands and "unconventional MHC"
• "new Tac" FVB mice
• Characterization of the mutant strain
• The Taconic defect is in the stromal compartment
• Skint1 structure and possible topology
• Is Skint-1 a positively selecting agonist?
• Molecules that regulate unconventional T cells
• Recognition by human gamma-delta T cells
• Peripheral gamma-delta cell response to infection
• Non-peptide activators produced by parasites
• Clinical trial: Francesco Dieli
• Palermo
• Cell subset dynamics in response to treatment
• Gamma-delta responses in a caner patient

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 15, 2009

Financial Disclosures

• Prof. Adrian Hayday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.