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1. Introduction
2. Outline
3. Innate-like cells and protection of the young animal
4. Waves of gamma-delta cell development
5. Testing immunological mechanisms
6. Th1 protection by alpha-beta T cells
7. T-cells in young mice
8. Gamma-delta cells confer young mice resistance
9. Working model for gamma-delta cells
10. Studying the situation in human neonates
11. Cytokines production by different T-cells
12. Precocious activation of gamma-delta T cells
13. Section 3: interim conclusions
14. Toll like receptors and their ligands
15. Gamma-delta cells in pre-term neonates (1)
16. Gamma-delta cells in pre-term neonates (2)
17. Summary of section 3
18. Ligands for innate-like / unconventional T cells
19. Ligands and "unconventional MHC" - iNKT
20. Ligands and "unconventional MHC" - MAIT cells
21. Ligands and "unconventional MHC" - gamma-delta
22. Unconventional T cell "ligands"
23. "New Tac" FVB mice
24. Characterization of the mutant strain
25. The Taconic defect is in the stromal compartment
26. Skint1 structure and possible topology
27. The efficacy of Skint-1
28. What is Skint-1?
29. Skint-1 expressed in the thymus and skin
30. Summary of gamma-delta cell selection
31. Is Skint-1 a positively selecting agonist?
32. Molecules that regulate unconventional T cells
33. Recognition by human gamma-delta T cells
34. Peripheral gamma-delta cell response to infection
35. Non-peptide activators produced by parasites
36. Sources of activators for human gamma-delta cells
37. Clinical trial: Francesco Dieli - Palermo
38. Cell subset dynamics in response to treatment
39. Gamma-delta responses in a cancer patient
40. Data so far... clinical outcome
41. Human peripheral blood Vgamma9Vdelta2+ cells

Topics Covered

• Innate-like cells and protection of the young animal
• Waves of gamma-delta cell development
• Th1 protection by alpha-beta T cells
• Gamma-delta cells confer young mice resistance
• Studying the situation in human neonates
• Cytokines production by different T-cells
• Toll like receptors and their ligands
• Gamma-delta cells in pre-term neonates
• Ligands and "unconventional MHC"
• "new Tac" FVB mice
• Characterization of the mutant strain
• The Taconic defect is in the stromal compartment
• Skint1 structure and possible topology
• Is Skint-1 a positively selecting agonist?
• Molecules that regulate unconventional T cells
• Recognition by human gamma-delta T cells
• Peripheral gamma-delta cell response to infection
• Non-peptide activators produced by parasites
• Clinical trial: Francesco Dieli
• Palermo
• Cell subset dynamics in response to treatment
• Gamma-delta responses in a caner patient

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 15, 2009

Financial Disclosures

• Prof. Adrian Hayday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.