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1. Introduction
2. Inflammation in the CNS
3. Macrophage populations of the CNS
4. Perivascular macrophages
5. Regulation of the microglia phenotype
6. Microglia sensors of pathology
7. Models of macrophage activation
8. Acute vs. persistent stimuli
9. Inflammation in Alzheimer's disease
10. A model of chronic neurodegeneration
11. Prion pathology at 13 weeks
12. Evolution of prion disease
13. Cytokine profile in prion disease
14. Clearance of apoptotic cells
15. Neuronal death in prion disease
16. Synaptic loss revealed by synaptophysin staining
17. Differences between prion and Alzheimer's disease
18. Communication in sickness behavior
19. Prion diseased mice injected with endotoxin
20. The profile in prion disease and LPS challenge
21. Microglia priming in prion disease
22. Priming in the prion diseased parenchyma
23. Activated caspase-3 immunocytochemistry
24. Are prion models relevant to Alzheimer's disease?
25. Infection in Alzheimer's disease
26. Clinical studies
27. Systemic infections and rates of decline
28. Systemic infections and sickness behavior
29. Systemic infections and cognitive decline
30. Concluding remarks
31. Acknowledgements

Topics Covered

• Macrophage populations in the brain
• Regulation of brain macrophage-microglia phenotype
• Inflammation in Alzheimer's disease
• Prion disease, a model of chronic neurodegeneration
• Behavioural assays
• Impact of systemic infections/inflammation on the brain
• Interactions between systemic inflammation and brain disease
• Microglia switching
• Relevance to Alzheimer's disease?
• Impact of systemic infections on Alzheimer's disease progression

Links

Series:

• Innate Immunity

Categories:

• Immunology
• Neuroscience

Therapeutic Areas:

• Immunology & Inflammation
• Neurology

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. V. Hugh Perry has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.