• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Talk outline
3. The human intestinal tract
4. Location of Paneth cells
5. Paneth cells - background (1)
6. Paneth cells - background (2)
7. Paneth cells - ultrastructure
8. Lysozyme
9. Paneth cell defensins
10. Matrilysin processes PC-derived defensins
11. Defensins protect against Salmonella infection (1)
12. Defensins protect against Salmonella infection (2)
13. PC secrete defensins in response to bacteria
14. Symbiotic bacteria induce RegIII in PC
15. Paneth cells express an antibacterial sPLA2
16. Intestinal secretory PLA2
17. Antimicrobial gene expression in human PC
18. Paneth cells - zinc
19. Paneth cells - IgA
20. Ablation of Paneth cells
21. Gene expression in Paneth cells
22. TNFalpha gene expression in murine PC
23. TNFalpha is expressed in PC in Crohn's disease
24. TNFdeltaARE mice over-express TNFalpha
25. TNFdeltaARE mice develop Crohn's-like ileitis
26. TNF-induced lethal shock - mediated by IL-17
27. IL-23 localized to PC in ankylosing spondylitis
28. Local CSF1 is required for PC differentiation
29. IL-9 mediates PC differentiation
30. Immune cells mediate antimicrobial effect via PC
31. PC involvement in IBD pathogenesis
32. Ulcerative colitis and Crohn's disease = IBD
33. Normal and Crohn's affected intestine
34. NOD2 gene and Crohn's disease
35. NOD2 mutations are associated with ileal Crohn's
36. NOD2 RNA is constitutively expressed in PC
37. NOD2 mRNA is expressed in microdissected PC
38. NOD2 protein is localized to PC cytoplasm
39. NOD2 levels are similar in monocytes and PC
40. NOD2 mRNA in monocytes vs. macrophages (1)
41. NOD2 mRNA in monocytes vs. macrophages (2)
42. Paneth cells secretion assay
43. Control of Paneth cell secretion
44. PC are highly responsive to MDP
45. Imbalance of enteric bacteria cause IBD
46. Crohn's disease: a defensin deficiency syndrome?
47. Defensin expression regulated by inflammation
48. Effect of NOD2 mutations (1)
49. Effect of NOD2 mutations (2)
50. APC and beta-catenin promote differentiation of PC
51. Beta-catenin and TCF4 regulate alpha-defensins
52. SOX-9 is required for differentiation of PC
53. Beta-catenin signalling
54. PPAR genes regulate the differentiation of PC
55. ATG16L, IRGM associated with Crohn's disease
56. ATG16L mutation affects the morphology of PC
57. PC in immunity and inflammation
58. Summary

Topics Covered

• Position and structure of Paneth cells
• Produce diverse protein products
• Ultrastructure
• Lysozyme
• Paneth cell defensins
• Salmonella infection
• Antimicrobial function
• Zinc
• IgA
• Effects of lineage ablation
• TNFalfa
• Expression of immune-related genes
• Potential role in human disease
• Are Paneth cells involved in the pathogenesis of IBD?
• Ulcerative colitis and Crohn's disease
• The NOD2 gene
• Control of Paneth cell secretion
• Paneth cells highly responsive to MPD
• Defensin expression
• Paneth cell morphology and gene expression are altered in IBD

Links

Series:

• Innate Immunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 8, 2009

Financial Disclosures

• Prof. Satish Keshav has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.